Initiatives of artisanal fisheries co-management and the construction of differentiated markets for seafood products have been emerging in different parts of the world, as an institutionalized way of coping with a global fishery crisis. This paper analyses some institutionalization processes of artisanal mollusc fisheries, considering the role of co-management in two Brazilian and Italian protected areas (Resex Pirajuba´e and Conero Regional Park). Within a theoretical framework aiming at moving beyond the dualism between nature and society, the methodology of multiple-case-study has been used to carry on research about mollusc artisanal fisheries comanagement networks in their constitution and development. The paper analyses how these networks are organised in the two contexts and the relations social actors have been developing for a sustainable fishery as a possible way to influence and increase their capacity to address environmental crisis. In the artisanal mollusc fishery co-management experiences, fishers’ participation may favour institutional innovations and the comanagement networks stability may be generated by the institutions legitimacy. Furthermore, the case studies offer complementary insights to better understand the linkage between artisanal fishery institutionalization processes, common natural resources co-management and value aggregation for traditional seafood. Artisanal mollusc fishery co-management experiences should be stimulated and investigated since they can help in diagnosing early climate and environmental changes in the oceans.