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Latenciação e formas avançadas de transporte de fármacos
Registro en:
Revista Brasileira de Ciências Farmacêuticas. Divisão de Biblioteca e Documentação do Conjunto das Químicas da Universidade de São Paulo, v. 41, n. 2, p. 155-180, 2005.
1516-9332
10.1590/S1516-93322005000200004
S1516-93322005000200004
S1516-93322005000200004.pdf
2-s2.0-26244457606
Autor
Chung, Man-Chin
Silva, Antonio Távora de Albuquerque
Castro, Lúcia Fioravanti
Güido, Rafael Victório Carvalho
Nassute, José Carlos
Ferreira, Elizabeth Igne
Resumen
O processo de modificação molecular denominado latenciação é revisto, apresentando formas avançadas no transporte de fármacos, utilizando macromoléculas como transportadores e sistemas de liberação sítio-específica como: CDS (Chemical Delivery System), ADEPT (Antibody-Directed Enzyme Prodrug Therapy), GDEPT/VDEPT (Gene-Directed Enzyme Prodrug Therapy/Vírus-Directed Enzyme Prodrug Therapy), ODDS (Osteotropic Drug Delivery System), PDEPT (Polymer-Directed Enzyme Prodrug Therapy), PELT (Polymer-Enzyme Liposome Therapy) e LEAPT (Lectin-Directed Enzyme-Activated Prodrug Therapy). This is a review about the molecular modification process, called latentiation, or prodrug design, focusing the progress in the prodrug approach using macromolecules as carriers and drug target systems as: PDEPT ( Polymer-Directed Enzyme Prodrug Therapy); PELT (Polymer-Enzyme Liposome Therapy); CDS (Chemical Delivery System); ADEPT(Antibody-Directed Enzyme Prodrug Therapy; GDEPT/VDEPT (Gene-Directed Enzyme Prodrug Therapy/Virus-Directed Enzyme Prodrug Therapy and ODDS (Osteotropic Drug Delivery System) and LEAPT (Lectin-Directed Enzyme-Activated Prodrug Therapy).