Otro
A duplicated nitrotienyl derivative with antimycobacterial activity: synthesis, X-ray crystallography, biological and mutagenic activity tests
Registro en:
European Journal of Medicinal Chemistry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 41, n. 10, p. 1196-1200, 2006.
0223-5234
10.1016/j.ejmech.2006.04.009
WOS:000241909800009
Autor
Rando, D. G.
Doriguetto, A. C.
de Paula da Silva, C. H. Tomich
Ellena, J.
Sato, D. N.
Leite, Clarice Queico Fujimura
Varanda, Eliana Aparecida
Ferreira, E. I.
Resumen
A duplicated nitrotienyl derivative was obtained as a by-product from the synthesis of a proposed molecular hybrid of a nitrotienyl derivative and isoniazid with an expected dual antimycobacteria mechanism. The structure was shown to be the 5,5'-dinitro-2(2,3-diaza-4-(2'-tienyl)buta-1,3-dienyl)tiophene by X-ray crystallography. The minimal inhibitory concentration (MIC) determination of this compound proved to be promising against Mycobacterium pathogenic strains such as M. avium and M. kansasei, although it had a high level of mutagenicity, as observed in mutagenic activity tests. (c) 2006 Elsevier Masson SAS. All rights reserved.