A duplicated nitrotienyl derivative with antimycobacterial activity: synthesis, X-ray crystallography, biological and mutagenic activity tests

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorRando, D. G.
dc.creatorDoriguetto, A. C.
dc.creatorde Paula da Silva, C. H. Tomich
dc.creatorEllena, J.
dc.creatorSato, D. N.
dc.creatorLeite, Clarice Queico Fujimura
dc.creatorVaranda, Eliana Aparecida
dc.creatorFerreira, E. I.
dc.date2014-05-20T13:24:23Z
dc.date2016-10-25T16:45:05Z
dc.date2014-05-20T13:24:23Z
dc.date2016-10-25T16:45:05Z
dc.date2006-10-01
dc.date.accessioned2017-04-05T19:59:53Z
dc.date.available2017-04-05T19:59:53Z
dc.identifierEuropean Journal of Medicinal Chemistry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 41, n. 10, p. 1196-1200, 2006.
dc.identifier0223-5234
dc.identifierhttp://hdl.handle.net/11449/7536
dc.identifierhttp://acervodigital.unesp.br/handle/11449/7536
dc.identifier10.1016/j.ejmech.2006.04.009
dc.identifierWOS:000241909800009
dc.identifierhttp://dx.doi.org/10.1016/j.ejmech.2006.04.009
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/856153
dc.descriptionA duplicated nitrotienyl derivative was obtained as a by-product from the synthesis of a proposed molecular hybrid of a nitrotienyl derivative and isoniazid with an expected dual antimycobacteria mechanism. The structure was shown to be the 5,5'-dinitro-2(2,3-diaza-4-(2'-tienyl)buta-1,3-dienyl)tiophene by X-ray crystallography. The minimal inhibitory concentration (MIC) determination of this compound proved to be promising against Mycobacterium pathogenic strains such as M. avium and M. kansasei, although it had a high level of mutagenicity, as observed in mutagenic activity tests. (c) 2006 Elsevier Masson SAS. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationEuropean Journal of Medicinal Chemistry
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectnitrotienyl derivative
dc.subjectpotential antimycobacterial agent
dc.subjectx-ray structure determination
dc.subjectantimycobacterial activity
dc.subjectmutagenicity
dc.titleA duplicated nitrotienyl derivative with antimycobacterial activity: synthesis, X-ray crystallography, biological and mutagenic activity tests
dc.typeOtro


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