The pharmaceutical industry currently has computer systems that seek to optimize processes and allow the maximum performance of its resources through the use of computer tools. The objective of the work was to determine the costs and benefits of two different software in management of raw materials for the pharmaceutical industry. Methods: observational, descriptive, cross-sectional, study that compared ONDANET and SAP software in positive and negative costs inferred in the implementation of the tools and the benefits in terms of the profitability of the management of raw materials for the elaboration of pharmaceutical products. Results: it has been observed by using direct costs and benefits that the benefit-cost ratio of the SAP software implementation yielded a result of 15.37, whereas the ONDANET software presented a cost-benefit ratio of 0.05, which could have been demonstrated Conclusion: A widely favorable cost-benefit ratio was found for SAP Software compared to the previously used ONDANET Software, indicating that the new software used is profitable. It is desirable to periodically carry out this type of analysis to guarantee not only that the Pharmaceutical Industry has a greater profitability, without also being able to provide its products with continuity and at affordable prices for the population.