Fil: Blutt, Sarah E. Department of Molecular Virology and Microbiology, Baylor College of Medicine; Estados Unidos.Fil: Kirkwood, Carl D. Enteric Virus Research Group, Murdoch Childrens Research Institute, Royal Children’s Hospital, Department of Paediatrics, University of Melbourne; Australia.Fil: Parreño, Viviana. Instituto de Virologia, CICVyA, INTA; ArgentinaFil: Warfield, Kelly L. Department of Molecular Virology and Microbiology, Baylor College of Medicine; Estados Unidos.Fil: Ciarlet, Max. Department of Molecular Virology and Microbiology, Baylor College of Medicine; Estados Unidos.Fil: Estes, Mary K. Department of Molecular Virology and Microbiology, Baylor College of Medicine; Estados Unidos.Fil: Bok, Karin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina.Fil: Bishop, Ruth F. Enteric Virus Research Group, Murdoch Childrens Research Institute, Royal Children’s Hospital, Department of Paediatrics, University of Melbourne; Australia.Fil: Conner, Margaret E. Department of Molecular Virology and Microbiology, Baylor College of Medicine; Estados Unidos.Rotavirus infection is thought to be confined to the intestine. Reports of rotavirus RNA in the cerebral spinal fluid and serum of children infected with rotavirus suggest the possibility that rotavirus escapes the intestine into the circulatory system. We assessed whether rotavirus antigen, RNA, or both, were present in serum samples from immunocompetent rotavirus-infected children and animals.