Artículo
Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings
Registro en:
10.1038/ng.3644
Autor
Feasey, Nicholas A
Hadfield, James
Keddy, Karen H
Dallman, Timothy J
Jacobs, Jan
Deng, Xiangyu
Wigley, Paul
Barquist, Lars
Langridge, Gemma C
Feltwell, Theresa
Harris, Simon R
Mather, Alison E
Fookes, Maria
Aslett, Martin
Msefula, Chisomo
Kariuki, Samuel
Maclennan, Calman A
Onsare, Robert S
Weill, François-Xavier
Le Hello, Simon
Smith, Anthony M
McClelland, Michael
Desai, Prerak
Parry, Christopher M
Cheesbrough, John
French, Neil
Campos, Josefina
Chabalgoity, Jose A
Betancor, Laura
Hopkins, Katie L
Nair, Satheesh
Humphrey, Tom J
Lunguya, Octavie
Cogan, Tristan A
Tapia, Milagritos D
Sow, Samba O
Tennant, Sharon M.
Bornstein, Kristin
Levine, Myron M
Lacharme-Lora, Lizeth
Everett, Dean B
Kingsley, Robert A
Parkhill, Julian
Heyderman, Robert S
Dougan, Gordon
Gordon, Melita A
Thomson, Nicholas R
Resumen
Fil: Feasey, Nicholas A. Liverpool School of Tropical Medicine; Reino Unido. Fil: Hadfield, James. Wellcome Trust Sanger Institute; Reino Unido. Fil: Keddy, Karen H. National Institute for Communicable Diseases. Centre for Enteric Diseases; Sudáfrica. Fil: Dallman, Timothy J. Public Health England. Gastrointestinal Bacteria Reference Unit; Reino Unido. Fil: Jacobs, Jan. Institute of Tropical Medicine; Bélgica. Fil: Deng, Xiangyu. University of Georgia. Center for Food Safety, Department of Food Science and Technology; Estados Unidos. Fil: Wigley, Paul. University of Liverpool. Institute of Infection and Global Health; Reino Unido. Fil: Barquist, Lars. University of Würzburg. Institute for Molecular Infection Biology; Alemania. Fil: Langridge, Gemma C. Wellcome Trust Sanger Institute; Reino Unido. Fil: Feltwell, Theresa. Wellcome Trust Sanger Institute; Reino Unido. Fil: Harris, Simon R. Wellcome Trust Sanger Institute; Reino Unido. Fil: Mather, Alison E. Wellcome Trust Sanger Institute; Reino Unido. Fil: Fookes, Maria. Wellcome Trust Sanger Institute; Reino Unido. Fil: Aslett, Martin. Wellcome Trust Sanger Institute; Reino Unido. Fil: Msefula, Chisomo. University of Malawi. College of Medicine. Malawi Liverpool Wellcome Trust Clinical Research Programme; Malaui. Fil: Kariuki, Samuel. Kenya Medical Research Institute. Centre for Microbiology Research; Kenia. Fil: Maclennan, Calman A. Wellcome Trust Sanger Institute; Reino Unido. Fil: Onsare, Robert S. Kenya Medical Research Institute. Centre for Microbiology Research; Kenia. Fil: Weill, François-Xavier. Institut Pasteur; Francia. Fil: Le Hello, Simon. Institut Pasteur; Francia. Fil: Smith. Anthony M. National Institute for Communicable Diseases. Centre for Enteric Diseases; Sudáfrica. Fil: McClelland, Michael. University of California. Department of Microbiology and Molecular Genetics; Estados Unidos. Fil: Desai, Prerak. University of California. Department of Microbiology and Molecular Genetics; Estados Unidos. Fil: Parry, Christopher M. University of California. Department of Microbiology and Molecular Genetics; Estados Unidos. Fil: Cheesbrough, John. University of Liverpool. Department of Epidemiology and Population Health; Reino Unido. Fil: French, Neil. University of Liverpool. Institute of Infection and Global Health; Reino Unido. Fil: Campos, Josefina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Fil: Chabalgoity, Jose A. Universidad de la República. Facultad de Medicina. Instituto de Higiene; Uruguay. Fil: Betancor, Laura. Universidad de la República. Facultad de Medicina. Instituto de Higiene; Uruguay. Fil: Hopkins, Katie L. Public Health England. Antimicrobial Resistance and Healthcare-Associated Infections Reference Unit; Reino Unido. Fil: Nair, Satheesh. Public Health England. Gastrointestinal Bacteria Reference Unit; Reino Unido. Fil: Humphrey, Tom J. Swansea University. Swansea Medical School; Reino Unido. Fil: Lunguya, Octavie. National Institute of Biomedical Research, República Democrática del Congo. Fil: Cogan, Tristan A. University of Bristol. School of Veterinary Sciences; Reino Unido. Fil: Tapia, Milagritos D. University of Maryland. School of Medicine. Center for Vaccine Development; Estados Unidos. Fil: Sow, Samba O. Centre pour le Développement des Vaccins, Malí. Fil: Tennant, Sharon M. University of Maryland. School of Medicine. Center for Vaccine Development; Estados Unidos. Fil: Bornstein, Kristin. University of Maryland. School of Medicine. Center for Vaccine Development; Estados Unidos. Fil: Levine, Myron M. University of Maryland. School of Medicine. Center for Vaccine Development; Estados Unidos. Fil: Lacharme-Lora, Lizeth. University of Liverpool. Institute of Infection and Global Health; Reino Unido. Fil: Everett, Dean B. University of Liverpool. Institute of Infection and Global Health; Reino Unido. Fil: Kingsley, Robert A. Wellcome Trust Sanger Institute; Reino Unido. Fil: Parkhill, Julian. Wellcome Trust Sanger Institute; Reino Unido. Fil: Heyderman, Robert S. University of Malawi. College of Medicine. Malawi Liverpool Wellcome Trust Clinical Research Programme; Malaui. Fil: Dougan, Gordon. Wellcome Trust Sanger Institute; Reino Unido. Fil: Gordon, Melita A. University of Malawi. College of Medicine. Malawi Liverpool Wellcome Trust Clinical Research Programme; Malaui. Fil: Thomson, Nicholas R. Wellcome Trust Sanger Institute; Reino Unido. An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.