info:eu-repo/semantics/article
Antigen Detection in the Diagnosis of Histoplasmosis : A Meta-analysis of Diagnostic Performance
Registro en:
Fandiño-Devia E, Rodríguez-Echeverri C, Cardona-Arias J, Gonzalez A. Antigen Detection in the Diagnosis of Histoplasmosis: A Meta-analysis of Diagnostic Performance. Mycopathologia. 2016 Apr;181(3-4):197-205. doi: 10.1007/s11046-015-9965-3.
0301-486X
10.1007/s11046-015-9965-3
1573-0832
Autor
Fandiño Devia, Estefanía
Rodríguez Echeverri, Carolina
Cardona Arias, Jaiberth Antonio
González Marín, Ángel Augusto
Institución
Resumen
ABSTRACT : We performed a meta-analysis of diagnostic data to evaluate the performance of Histoplasma antigen detection tests for diagnosing histoplasmosis. We included all studies involving human subjects that assessed the performance of any antigen detection test for histoplasmosis in urine or serum by carrying out an exhaustive and reproducible search of the literature between 1980 and 2014 from four databases. Quality of the articles was assessed, and meta-analysis was performed under the random effects model, calculating sensitivity, specificity, likelihood and odds ratios, and ROC curve using Meta-DiSc(es). Nine out of a total of 23 studies met strict quality criteria and were therefore included. The overall sensitivity for antigen detection in serum and urine was 81 % (95 % CI 78–83 %), while specificity was 99 % (95 % CI 98–99 %). Sensitivity for antigenuria and antigenemia was 79 % (95 % CI 76–82 %) and 82 % (95 % CI 79–85 %), respectively; specificity values were 99 % (95 % CI 98–100 %) in urine and 97 % (95 % CI 96–98 %) in serum. The positive and negative likelihood ratios were 49.5 (95 % CI 20.7–118.7) and 0.19 (95 % CI 0.14–0.26), respectively, while the diagnostic OR was 362 (95 % CI 121.2–1080.3) and area under the curve was 0.99. In conclusion, the performance of Histoplasma antigen detection assay of urine was not significantly different from that of blood, indicating that antigenuria and antigenemia have equal diagnostic value in histoplasmosis. COL0126131 COL0088881