Estudio in vivo e in vitro del efecto antidiabético de un extracto de hojas de passiflora ligularis

dc.contributorOspina Giraldo, Luis Fernando
dc.contributorMena Barreto Silva, Fátima Regina
dc.contributorPrincipios Bioactivos en Plantas Medicinales
dc.contributorGrupo de Investigación en Tecnología de Productos Naturales Tecprona
dc.contributorDiana Patricia Rey [000000034517631X]
dc.contributorDiana Patricia Rey Padilla [0001395740]
dc.contributorDiana Rey [Diana-Rey]
dc.contributorDiana Patricia Rey Padilla [3HljxewAAAAJ&hl=es]
dc.creatorRey Padilla, Diana Patricia
dc.date.accessioned2023-08-08T14:26:24Z
dc.date.accessioned2023-08-25T13:56:59Z
dc.date.available2023-08-08T14:26:24Z
dc.date.available2023-08-25T13:56:59Z
dc.date.created2023-08-08T14:26:24Z
dc.date.issued2023-10-31
dc.identifierhttps://repositorio.unal.edu.co/handle/unal/84473
dc.identifierUniversidad Nacional de Colombia
dc.identifierRepositorio Institucional Universidad Nacional de Colombia
dc.identifierhttps://repositorio.unal.edu.co/
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8427034
dc.description.abstractIntroducción: La diabetes mellitus tipo 2 es una enfermedad de alta prevalencia e incidencia a nivel mundial, se estima que la población afectada por esta enfermedad siga en aumento en el transcurso de los próximos años, esta patología se caracteriza por una hiperglicemia crónica que si no es controlada conlleva a complicaciones cardiovasculares, neuropáticas, neurológicas, entre otras. Aunque actualmente se cuenta con varios tratamientos para el control de la glicemia y prevenir la aparición de las complicaciones asociadas a la misma, se sigue en búsqueda de nuevos tratamientos. Gran parte de la población mundial acude a la utilización de plantas medicinales para el tratamiento de sus enfermedades y aunque se ha reportado en la literatura el efecto antidiabético de varias plantas medicinales, es necesario profundizar en estudios que permitan establecer su actividad terapéutica, una de las especies en las que se ha evidenciado esta actividad, es la Passiflora ligularis, sin embargo se desconoce los metabolitos asociados a este efecto y su mecanismo de acción por ello se plantearon los siguientes objetivos. Los objetivos planteados fueron: evaluar el efecto antidiabético de un extracto de hojas de Passiflora ligularis (P. ligularis), identificar los metabolitos responsables de la actividad antidiabética de dicho extracto y la dilucidar un posible mecanismo de acción de los metabolitos responsables de dicha actividad antidiabética. (Texto tomado de la fuente)
dc.description.abstractIntroduction: Type 2 diabetes mellitus is a disease of high prevalence and incidence worldwide, it is estimated that the population affected by this disease will continue to increase in the coming years, this pathology is characterized by chronic hyperglycemia that if not controlled leads to cardiovascular, neuropathic, neurological complications, among others. Although there are currently several treatments to control glycemia and prevent the appearance of complications associated with it, the search for new treatments continues. A large part of the world population resorts to the use of medicinal plants for the treatment of their diseases and although the antidiabetic effect of various medicinal plants has been reported in the literature, it is necessary to deepen studies that allow establishing their therapeutic activity, one of the species in which this activity has been evidenced, is Passiflora ligularis, however the metabolites associated with this effect and its mechanism of action are unknown, therefore the following objectives were set. The proposed objectives were: evaluate the antidiabetic effect of an extract of Passiflora ligularis (P. ligularis) leaves, to identify the metabolites responsible for the antidiabetic activity of said extract and to elucidate a possible mechanism of action of the metabolites responsible for said antidiabetic activity.
dc.languagespa
dc.publisherUniversidad Nacional de Colombia
dc.publisherBogotá - Ciencias - Doctorado en Ciencias Farmacéuticas
dc.publisherFacultad de Ciencias
dc.publisherBogotá, Colombia
dc.publisherUniversidad Nacional de Colombia - Sede Bogotá
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dc.rightsAtribución-NoComercial 4.0 Internacional
dc.rightshttp://creativecommons.org/licenses/by-nc/4.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEstudio in vivo e in vitro del efecto antidiabético de un extracto de hojas de passiflora ligularis
dc.typeTrabajo de grado - Doctorado


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