| dc.creator | Guajardo, Nadia | |
| dc.creator | Bernal, Claudia | |
| dc.creator | Cabrera-Muñoz, Zaida Tamara | |
| dc.creator | Wilson, Lorena | |
| dc.date | 2018-09-03T15:44:46Z | |
| dc.date | 2022-06-18T22:01:20Z | |
| dc.date | 2018-09-03T15:44:46Z | |
| dc.date | 2022-06-18T22:01:20Z | |
| dc.date | 2013-09-06 | |
| dc.date | 2013 | |
| dc.date | 2013-09-01 | |
| dc.date.accessioned | 2023-08-23T00:36:57Z | |
| dc.date.available | 2023-08-23T00:36:57Z | |
| dc.identifier | 1130981 | |
| dc.identifier | https://hdl.handle.net/10533/219735 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8355803 | |
| dc.description | Optically active (α)-monobenzoate glycerol ((α)-MBG) is known to be a useful
starting compound for the preparation of chiral drugs, such as β blockers,
platelet activating factor and (S)-carnitine [1]. The reaction consists in an
enzymatic asymmetric esterification of benzoic acid in the α-hydroxil group of
glycerol. Figure 1 shows the reaction system. The activity, stability and
operational selectivity of lipases as a catalyst in organic synthesis can be
controlled by immobilization and the reaction media [2]. There are many
strategies of immobilization, which promote differents ways of enzyme
orientations that could modulate the enantioselectivity. For this purpouse,
support with different activation, as hydrophobic and epoxide groups, allow
enzyme immobilization by adsorption and/or covalent attachmente [3]. The
present work was focused to studied the enantioselectivity of the esterification
reaction to produce (R)-MBG in 1, 4 dioxane evaluating the effect of lipase
orientation during the immobilization according to support used and the
substrates ratio in the reaction. | |
| dc.language | eng | |
| dc.relation | instname: Conicyt | |
| dc.relation | reponame: Repositorio Digital RI2.0 | |
| dc.relation | European Congress on Catalysis (EuropaCat) | |
| dc.relation | 11 | |
| dc.relation | info:eu-repo/grantAgreement//1130981 | |
| dc.relation | info:eu-repo/semantics/dataset/hdl.handle.net/10533/93486 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| dc.title | Production of optically active (α)-monobenzoyl glycerol catalyzed by CALB lipase immobilized on silica octyl Support | |
| dc.type | Ponencia | |
| dc.type | info:eu-repo/semantics/lecture | |
| dc.coverage | Lyon | |
