BEHAVIOURAL BRAIN RESEARCH

dc.creatorVergara-Vergara, Macarena del Pilar
dc.creatorKeller, Victor N
dc.creatorFuentealba, José A
dc.creatorGysling-Caselli, Katia Cecilia
dc.date2021-08-23T22:58:55Z
dc.date2022-07-07T14:55:44Z
dc.date2021-08-23T22:58:55Z
dc.date2022-07-07T14:55:44Z
dc.date2017
dc.date.accessioned2023-08-23T00:05:31Z
dc.date.available2023-08-23T00:05:31Z
dc.identifier1150244
dc.identifier1150244
dc.identifierhttps://hdl.handle.net/10533/252443
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8353758
dc.descriptionThe prelimbic area (PL) of the medial Prefrontal cortex (mPFC) is involved in the acquisition and expression of conditioned and innate fear. Both types of fear share several neuronal pathways. It has been documented that dopamine (DA) plays an important role in the regulation of aversive memories in the mPFC. The exposure to an aversive stimulus, such as the smell of a predator odor or the exposure to footshock stress is accompanied by an increase in mPFC DA release. Evidence suggests that the type 4 dopaminergic receptor (D4R) is the molecular target through which DA modulates fear expression. In fact, the mPFC is the brain region with the highest expression of D4R; however, the role of D4R in the expression of innate fear has not been fully elucidated. Therefore, the principal objective of this work was to evaluate the participation of mPFC D4R in the expression of innate fear. Rats were exposed to the elevated plus-maze (EPM) and to the cat odor paradigm after the intra PL injection of L-745,870, selective D4R antagonist, to measure the expression of fear-related behaviors. Intra PL injection of L-745,870 increased the time spent in the EPM open arms and decreased freezing behavior in the cat odor paradigm. Our results also showed that D4R is expressed in GABAergic and pyramidal neurons in the PL region of PFC. Thus, D4R antagonism in the PL decreases the expression of innate fear-behavior indicating that the activation of D4R in the PL is necessary for the expression of innate fear-behavior. (C) 2017 Elsevier B.V. All rights reserved.
dc.descriptionRegular 2015
dc.descriptionFONDECYT
dc.descriptionFONDECYT
dc.languageeng
dc.relationhandle/10533/111557
dc.relationhandle/10533/111541
dc.relationhandle/10533/108045
dc.relationhttps://doi.org/10.1016/j.bbr.2017.01.050
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsinfo:eu-repo/semantics/article
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleActivation of type 4 dopaminergic receptors in the prelimbic area of medial prefrontal cortex is necessary for the expression of innate fear behavior
dc.titleBEHAVIOURAL BRAIN RESEARCH
dc.typeArticulo
dc.typeinfo:eu-repo/semantics/publishedVersion


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