The association of VDR polymorphisms and type 2 diabetes in older people living in community in Santiago de Chile
Nutrition & Diabetes
| dc.creator | Lera, Lydia | |
| dc.creator | Angel-Badillo, Barbara Karen | |
| dc.creator | Marquez, Carlos | |
| dc.creator | Albala, Cecilia | |
| dc.date | 2018-07-03T20:03:46Z | |
| dc.date | 2022-07-07T15:01:40Z | |
| dc.date | 2018-07-03T20:03:46Z | |
| dc.date | 2022-07-07T15:01:40Z | |
| dc.date | 2018 | |
| dc.date.accessioned | 2023-08-23T00:04:04Z | |
| dc.date.available | 2023-08-23T00:04:04Z | |
| dc.identifier | 3100114 | |
| dc.identifier | 3100114 | |
| dc.identifier | https://hdl.handle.net/10533/215245 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8353664 | |
| dc.description | Introduction: Several polymorphisms have been associated with obesity and type 2 diabetes in different populations. Objective: To investigate the frequencies of a genetic polymorphism of vitamin D receptor (FokI and BsmI) in patients with T2D. Methods: The case-control study was conducted in 138 patients with T2D and 172 control subjects, men and women (60-79 years old). The genotype and allele frequency determination of VDR polymorphisms were determined in these subjects. Results: The frequency of the C allele of the FokI polymorphism was significantly higher in the T2D group than in healthy subjects (p = 0.025). The frequencies of the BsmI variant were similar in subjects with and without T2D (p = 0.747). Consistent with these data, there was an association of the C allele with T2D (OR = 1.74, 95% CI = 1.003-3.084, p = 0.036), but not the AG + GG variants for BsmI (OR = 1.02, 95% CI = 0.635-1.649, p = 0.916). We can observe a significant association between carrier of the T > C variant of FokI and type 2 diabetes, adjusted for vitamin D, age, obesity (overweight and obesity), seasonality, sex and Homa-IR. Here, we show a significant association between the FokI polymorphisms (TC + CC) and T2D with an odds ratio of 1.9001 (95% CI (1.0970-3.6838), p = 0.041). Conclusion: Our study suggests that the C allele (TC + CC) of the VDR-FokI gene is a possible risk factor for T2D in older people living in a community in Santiago de Chile. Keywords . KeyWords Plus:VITAMIN-D-RECEPTOR; ASSESSMENT HOMA VALUES; D DEFICIENCY; 25-HYDROXYVITAMIN D; GENE POLYMORPHISMS; INSULIN-RESISTANCE; METABOLIC SYNDROME; RISK; PREVENTION; MELLITUS | |
| dc.language | eng | |
| dc.relation | instname: Conicyt | |
| dc.relation | reponame: Repositorio Digital RI2.0 | |
| dc.relation | info:eu-repo/grantAgreement//3100114 | |
| dc.relation | info:eu-repo/semantics/dataset/hdl.handle.net/10533/93477 | |
| dc.relation | https://www.nature.com/articles/s41387-018-0038-9 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| dc.title | The association of VDR polymorphisms and type 2 diabetes in older people living in community in Santiago de Chile | |
| dc.title | Nutrition & Diabetes | |
| dc.type | Articulo | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion |