Supramolecular hydrogels of beta-cyclodextrin linked to calcium homopoly-L-guluronate for release of coumarins with trypanocidal activity

Carbohydrate Polymers

dc.creatorMoncada-Basualto, Mauricio
dc.creatorMatsuhiro, Betty
dc.creatorLapier, Michel
dc.creatorMaya, Juan Diego
dc.creatorOlea-Azar, Claudio Alberto
dc.date2021-08-23T22:58:31Z
dc.date2022-07-07T02:46:25Z
dc.date2021-08-23T22:58:31Z
dc.date2022-07-07T02:46:25Z
dc.date2019
dc.date.accessioned2023-08-22T23:13:38Z
dc.date.available2023-08-22T23:13:38Z
dc.identifier1150175
dc.identifier1150175
dc.identifierhttps://hdl.handle.net/10533/252321
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8350257
dc.descriptionAssociation constants and thermodynamicsparameters on inclusion of four 3-amido coumarins that present trypanocidal activity, into 6-amino-beta-cyclodextrin (1: 1 stoichimetry) were determined. In addition, pure homopolymeric-a-L-guluronate fraction prepared by partial hydrolysis of sodium alginate from Sub-Antarctic Kelp Durvillaea antarctica was conjugated with 6-amino-beta-cyclodextrin (64% yield). To glycoconjugates, 3-amido coumarins were incorporated (73% of encapsulation) and supramolecular hydrogels were prepared by gelation with Ca2+ ions. The trypanocidal activity of the inclusion complexes increased by 10%. Likewise, an increase in diffusion in artificial membrane was observed (13%). It was found that the inclusion complexes increased the variation of the mitochondrial potential of T. cruzi (17%). The lowest release of substituted amidocoumarins (ACS) from supramolecular hydrogels occurred at pH 1.2 whereas the maximum release (34%) was observed at pH 8.0. Encapsulation of lipophilic bioactive compounds in supramolecular hydrogels allows the generation of release systems sensitive to pH with potential application in biomedicine. Keywords- Author Keywords:Homopoly-L-guluronate; 3-Amidocoumarins; Inclusion complex; Trypanosoma cruzi; Supramolecular hydrogel; Sub-Antarctic macroalgae . KeyWords Plus:HOST-GUEST INTERACTIONS; POLY-D-MANNURONATE; TRYPANOSOMA-CRUZI; DRUG-DELIVERY; SODIUM ALGINATE; BIOMEDICAL APPLICATIONS; DURVILLAEA-ANTARCTICA; INCLUSION COMPLEXES; BLOCK FRACTIONS; HYDROPHILIC POLYMERS
dc.descriptionRegular 2015
dc.descriptionFONDECYT
dc.descriptionFONDECYT
dc.languageeng
dc.relationhandle/10533/111557
dc.relationhandle/10533/111541
dc.relationhandle/10533/108045
dc.relationhttps://doi.org/10.1016/j.carbpol.2018.10.010
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsinfo:eu-repo/semantics/article
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleSupramolecular hydrogels of beta-cyclodextrin linked to calcium homopoly-L-guluronate for release of coumarins with trypanocidal activity
dc.titleCarbohydrate Polymers
dc.typeArticulo
dc.typeinfo:eu-repo/semantics/publishedVersion


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