Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity

Autoimmunity Reviews

dc.creatorRecalde, Gabriela
dc.creatorMoreno-Sosa, Tamara
dc.creatorYudica, Florencia
dc.creatorQuintero, Cristian A
dc.creatorSánchez, María Belén
dc.creatorJahn, Graciela A
dc.creatorKalergis-Parra, Alexis Mikes
dc.creatorMackern-Oberti, Juan Pablo
dc.date2019-08-28T17:14:55Z
dc.date2022-07-07T21:53:47Z
dc.date2019-08-28T17:14:55Z
dc.date2022-07-07T21:53:47Z
dc.date2018
dc.date.accessioned2023-08-22T23:01:33Z
dc.date.available2023-08-22T23:01:33Z
dc.identifier1150862
dc.identifier1150862
dc.identifierhttps://hdl.handle.net/10533/236519
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8349426
dc.descriptionIn this review we discuss how sex steroids and prolactin affect regulation and responsiveness of B and T cells. Sex hormones exert profound effects on several physiological processes of non- reproductive tissues. In the immune system, several studies with experimental models for SLE have shown a noticeable pro-inflammatory role for ER alpha, contributing to disease development reflected in proteinuria and renal pathology. On the other hand, ER beta appears to have an anti- inflammatory and immunosuppressive effect. Estrogen/ER alpha signaling induced an increase of Th17 cells in lymph nodes as well as the expression of its correspondent chemokine receptor CCR6 during collagen induced arthritis acute phase. High levels of anti- DNA antibodies and increased mortality was observed when given high E and prolactin doses to NZB/NZW mice, as compared with mice receiving low E and prolactin doses, or high E and low prolactin doses. Intracellular progesterone receptors have been detected in TCD4(+) cells but in contrast as observed with ERs, it suppresses T cell dependent responses. Progestagen administration on female NZB/NZW mice decreased anti DNA IgG, improved survival, decreased glomerulonephritis and proteinuria. (C) 2018 Elsevier B.V. All rights reserved. Keywords. Author Keywords:Autoimmunity; Estrogen; Progesterone; Prolactin; T cells; B cells
dc.relationinstname: Conicyt
dc.relationreponame: Repositorio Digital RI2.0
dc.relationinfo:eu-repo/grantAgreement//1150862
dc.relationinfo:eu-repo/semantics/dataset/hdl.handle.net/10533/93477
dc.relationhttps://www.sciencedirect.com/science/article/pii/S1568997218300569?via%3Dihub
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.titleContribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity
dc.titleAutoimmunity Reviews
dc.typeArticulo
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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