| dc.creator | Nardocci, Gino | |
| dc.creator | Martín, Aldo | |
| dc.creator | Abarzúa, Sebastián | |
| dc.creator | Rodríguez, Jorge | |
| dc.creator | Simon, Felipe | |
| dc.creator | Reyes, Edison P. | |
| dc.creator | Acuña-Castillo, Claudio | |
| dc.creator | Navarro, Cristina | |
| dc.creator | Cortes, Paula | |
| dc.creator | Fernández, Ricardo | |
| dc.date | 2019-11-08T12:58:08Z | |
| dc.date | 2022-07-07T21:54:47Z | |
| dc.date | 2019-11-08T12:58:08Z | |
| dc.date | 2022-07-07T21:54:47Z | |
| dc.date | 2015 | |
| dc.date.accessioned | 2023-08-22T10:21:13Z | |
| dc.date.available | 2023-08-22T10:21:13Z | |
| dc.identifier | 21151265 | |
| dc.identifier | 21151265 | |
| dc.identifier | https://hdl.handle.net/10533/236603 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8339567 | |
| dc.description | Sepsis progresses to multiple organ dysfunction (MOD) due to the uncontrolled release of inflammatory mediators. Carotid chemo/baro-receptors could play a protective role during sepsis. In anesthetized male rats, we measured cardiorespiratory variables and plasma TNF-α, glucocorticoids, epinephrine, and MOD marker levels 90 min after lipopolysaccharide (LPS) administration in control (SHAM surgery) and bilateral carotid chemo/baro-denervated (BCN) rats. BCNprior to LPS blunted the tachypneic response and enhanced tachycardia and hypotension. BCN-LPS rats also showed blunted plasma glucocorticoid responses, boosted epinephrine and TNF-α responses, and earlier MOD onset with a lower survival time compared with SHAM-LPS rats. Consequently, the complete absence of carotid chemo/baro-sensory function modified the neural, endocrine and inflammatory responses to sepsis. Thus, carotid chemo/baro-receptors play a protective role in sepsis. | |
| dc.format | application/pdf | |
| dc.relation | instname: Conicyt | |
| dc.relation | reponame: Repositorio Digital RI2.0 | |
| dc.relation | info:eu-repo/grantAgreement//21151265 | |
| dc.relation | info:eu-repo/semantics/dataset/hdl.handle.net/10533/93477 | |
| dc.relation | https://www.ncbi.nlm.nih.gov/pubmed/25595251 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| dc.title | Sepsis progression to multiple organ dysfunction in carotid chemo/baro-denervated rats treated with lipopolysaccharide | |
| dc.type | Articulo | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
