ALTERNATIVE FUNCTIONS OF THE BCL-2 PROTEIN FAMILY AT THE ENDOPLASMIC RETICULUM

BCL-2 PROTEIN FAMILY. ESSENTIAL REGULATORS OF CELL DEATH

dc.creatorCaballero Bendixsen, Benjamin
dc.creatorHetz Flores, Claudio Andres
dc.creatorLisbona Pizarro, Maria Fernanda
dc.creatorRojas Rivera, Diego Andres
dc.creatorZamorano Aliaga, Sebastian
dc.date2016-12-27T21:47:17Z
dc.date2022-06-17T21:11:13Z
dc.date2016-12-27T21:47:17Z
dc.date2022-06-17T21:11:13Z
dc.date2010
dc.date.accessioned2023-08-22T09:13:05Z
dc.date.available2023-08-22T09:13:05Z
dc.identifier1100176
dc.identifier978-1-4419-6706-0
dc.identifier978-1-4419-6705-3
dc.identifier978-1-4899-8535-4
dc.identifierhttps://hdl.handle.net/10533/164567
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8335678
dc.descriptionApoptosis is essential for maintenance of tissue homeostasis and its deregulation results in a variety of disease conditions. The BCL-2 family of proteins is a group of evolutionarily conserved regulators of cell death that comprises both anti- and pro-apoptotic members, that operate at the mitochondrial membrane to control caspase activation. Different BCL-2-related proteins are also located in the endoplasmic reticulum (ER), where important roles in organelle physiology are proposed. Adaptation to ER stress is mediated by the activation of a complex signal transduction pathway known as the unfolded protein response (UPR). Recent reports indicate that the ER stress sensor IRE1alpha, signals through the formation of a protein complex platform at the ER membrane, here termed the "UPRosome". Alternatively, BCL-2 family members are contained in other multiprotein complexes at the ER that are involved in the control of diverse cellular processes including calcium homeostasis, autophagy and ER morphogenesis. Here we describe the emerging concept that BCL-2 family members are important regulators of essential cellular processes beyond apoptosis.
dc.descriptionFONDECYT
dc.description1
dc.description145
dc.descriptionFONDECYT
dc.languageeng
dc.publisherSPRINGER
dc.relationinstname: Conicyt
dc.relationreponame: Repositorio Digital RI2.0
dc.relationinstname: Conicyt
dc.relationreponame: Repositorio Digital RI 2.0
dc.relationADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
dc.relationinfo:eu-repo/grantAgreement/Fondecyt/1100176
dc.relationinfo:eu-repo/semantics/dataset/hdl.handle.net/10533/93479
dc.relationhttp://www.springer.com/us/book/9781441967053
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleALTERNATIVE FUNCTIONS OF THE BCL-2 PROTEIN FAMILY AT THE ENDOPLASMIC RETICULUM
dc.titleBCL-2 PROTEIN FAMILY. ESSENTIAL REGULATORS OF CELL DEATH
dc.typeCapitulo de libro
dc.typeinfo:eu-repo/semantics/bookPart


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