The transcription factor ZEB1 promotes an aggressive phenotype in prostate cancer cell lines

ASIAN JOURNAL OF ANDROLOGY

dc.creatorOrellana-Serradell, Octavio Andrés
dc.creatorHerrera-Ramírez, Daniela Francisca
dc.creatorCastellón, Enrique A
dc.creatorContreras-Muñoz, Héctor Ruberly
dc.date2021-08-23T22:55:33Z
dc.date2022-07-07T02:32:51Z
dc.date2021-08-23T22:55:33Z
dc.date2022-07-07T02:32:51Z
dc.date2018
dc.date.accessioned2023-08-22T07:48:31Z
dc.date.available2023-08-22T07:48:31Z
dc.identifier1151214
dc.identifier1151214
dc.identifierhttps://hdl.handle.net/10533/251648
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8332270
dc.descriptionIt has been reported that one of the factors that promotes tumoral progression is the abnormal activation of the epithelial-mesenchymal transition program. This process is associated with tumoral cells acquiring invasive and malignant properties and has the transcription factor zinc finger E-box-binding homeobox 1 (ZEB1) as one of its main activators. However, the role of ZEB1 in promoting malignancy in prostate cancer (PCa) is still unclear. Here, we report that ZEB1 expression correlates with Gleason score in PCa samples and that expression of ZEB1 regulates epithelial-mesenchymal transition and malignant characteristics in PCa cell lines. The results showed that ZEB1 expression is higher in samples of higher malignancy and that overexpression of ZEB1 was able to induce epithelial-mesenchymal transition by upregulating the mesenchymal marker Vimentin and downregulating the epithelial marker E-Cadherin. On the contrary, ZEB1 silencing repressed Vimentin expression and upregulated E-Cadherin. ZEB1 expression conferred enhanced motility and invasiveness and a higher colony formation capacity to 22Rv1 cells whereas DU145 cells with ZEB1 silencing showed a decrease in those same properties. The results showed that ZEB1 could be a key promoter of tumoral progression toward advanced stages of PCa.
dc.descriptionRegular 2015
dc.descriptionFONDECYT
dc.descriptionFONDECYT
dc.languageeng
dc.relationhandle/10533/111557
dc.relationhandle/10533/111541
dc.relationhandle/10533/108045
dc.relationhttps://doi.org/10.4103/aja.aja_61_17
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsinfo:eu-repo/semantics/article
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleThe transcription factor ZEB1 promotes an aggressive phenotype in prostate cancer cell lines
dc.titleASIAN JOURNAL OF ANDROLOGY
dc.typeArticulo
dc.typeinfo:eu-repo/semantics/publishedVersion


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