Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals

JOURNAL OF INVESTIGATIVE MEDICINE

dc.creatorCataldo-Bascuñán, Luis Rodrigo
dc.creatorFernández-Verdejo, Rodrigo
dc.creatorSantos-Martin, José Luis
dc.creatorGalgani, José Eduardo
dc.date2021-08-23T22:48:24Z
dc.date2022-07-08T20:19:00Z
dc.date2021-08-23T22:48:24Z
dc.date2022-07-08T20:19:00Z
dc.date2018
dc.date.accessioned2023-08-22T05:35:27Z
dc.date.available2023-08-22T05:35:27Z
dc.identifier1150416
dc.identifier1150416
dc.identifierhttps://hdl.handle.net/10533/250142
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8324746
dc.descriptionMitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is a mitochondrial-derived peptide that attenuates weight gain and hyperinsulinemia when administered to high fat-fed mice. MOTS-c is therefore a potential regulator of metabolic homeostasis under conditions of high-energy supply. However, the effect of insulin resistance and obesity on plasma MOTS-c concentration in humans is unknown. To gain insight into MOTS-c regulation, we measured plasma MOTS-c concentration and analyzed its relationship with insulin sensitivity surrogates, in lean and obese humans (n=10 per group). Obese individuals had impaired insulin sensitivity as indicated by low Matsuda and high Homeostatic Model Assessment (HOMA) indexes. Although plasma MOTS-c concentration was similar in lean and obese individuals (0.48 +/- 0.16 and 0.52 +/- 0.15 ng/ml; p=0.60), it was correlated with HOMA (r=0.53; p<0.05) and Matsuda index (r=-0.46; p<0.05). Notably, when the groups were analyzed separately, the associations remained only in lean individuals. We conclude that plasma MOTS-c concentration is unaltered in human obesity. However, MOTS-c associates positively with insulin resistance mostly in lean individuals, indicating that plasma MOTS-c concentration depends on the metabolic status in this population. Such dependence seems altered when obesity settles. The implications of plasma MOTS-c for human metabolic homeostasis deserve future examination.
dc.descriptionRegular 2015
dc.descriptionFONDECYT
dc.descriptionFONDECYT
dc.languageeng
dc.relationhandle/10533/111557
dc.relationhandle/10533/111541
dc.relationhandle/10533/108045
dc.relationhttps://doi.org/10.1136/jim-2017-000681
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsinfo:eu-repo/semantics/article
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titlePlasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals
dc.titleJOURNAL OF INVESTIGATIVE MEDICINE
dc.typeArticulo
dc.typeinfo:eu-repo/semantics/publishedVersion


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