Synthesis of New (E)-2-(1H-Indole-3-ylcarbonyl)-3-heteroaryl-acrylonitriles via Microwave-Assisted Knoevenagel Condensation

JOURNAL OF CHEMISTRY

dc.creatorTreuer, Adriana V
dc.creatorDe La Torre, Pedro
dc.creatorGutierrez-Cabrera, Margarita Isabel
dc.date2021-08-23T22:50:40Z
dc.date2022-07-08T20:26:54Z
dc.date2021-08-23T22:50:40Z
dc.date2022-07-08T20:26:54Z
dc.date2017
dc.date.accessioned2023-08-22T02:28:00Z
dc.date.available2023-08-22T02:28:00Z
dc.identifier1150712
dc.identifier1150712
dc.identifierhttps://hdl.handle.net/10533/250657
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8310628
dc.descriptionGiven the broad spectrum of biological uses of heteroaryl-acrylonitrile derivatives, it is necessary to find simple methods to synthesize and diversify this family of compounds. We report a stereoselective synthesis of a series of new (E)-2-(1H-indole-3ylcarbonyl)-3-heteroaryl-acrylonitriles (3a-3i) obtained from 3-(cyanoacetyl) indole and heteroaryl-aldehydes under microwaveassisted Knoevenagel reaction at 300 W of potency and 100 degrees C. The desired derivatives (3a-3i) were obtained with variable yields (30-94%) and time reactions (8-90 min). All the heteroaryl-acrylonitriles were characterized by physicoanalytical techniques such IR, H-1, C-13 NMR, and electrospray mass spectrometry.
dc.descriptionRegular 2015
dc.descriptionFONDECYT
dc.descriptionFONDECYT
dc.languageeng
dc.relationhandle/10533/111557
dc.relationhandle/10533/111541
dc.relationhandle/10533/108045
dc.relationhttps://doi.org/10.1155/2017/8418930
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsinfo:eu-repo/semantics/article
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleSynthesis of New (E)-2-(1H-Indole-3-ylcarbonyl)-3-heteroaryl-acrylonitriles via Microwave-Assisted Knoevenagel Condensation
dc.titleJOURNAL OF CHEMISTRY
dc.typeArticulo
dc.typeinfo:eu-repo/semantics/publishedVersion


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