Thy-1/CD90 a Bidirectional and Lateral Signaling Scaffold

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

dc.creatorLeyton-Campos, Lisette
dc.creatorDíaz, Jorge
dc.creatorMartínez, Samuel
dc.creatorPalaciosi, Esteban
dc.creatorPérez-González, Leonardo Andrés
dc.creatorPérez, Ramer D
dc.date2021-08-23T22:51:09Z
dc.date2022-07-08T20:28:18Z
dc.date2021-08-23T22:51:09Z
dc.date2022-07-08T20:28:18Z
dc.date2019
dc.date.accessioned2023-08-22T02:16:37Z
dc.date.available2023-08-22T02:16:37Z
dc.identifier1150744
dc.identifier1150744
dc.identifierhttps://hdl.handle.net/10533/250734
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8309866
dc.descriptionThy-1/CD90 is a glycoprotein attached to the outer face of the plasma membrane with various functions, which depend on the context of specific physiological or pathological conditions. Many of these reported functions for Thy-1/CD90 arose from studies by our group, which identified the first ligand/receptor for Thy-1/CD90 as an integrin. This finding initiated studies directed toward unveiling the molecular mechanisms that operate downstream of Thy-1/CD90 activation, and its possible interaction with proteins in the membrane plane to regulate their function. The association of Thy-1/CD90 with a number of cell surface molecules allows the formation of extra/intracellular multiprotein complexes composed of various ligands and receptors, extracellular matrix proteins, intracellular signaling proteins, and the cytoskeleton. The complexes sense changes that occur inside and outside the cells, with Thy-1/CD90 at the core of this extracellular molecular platform. Molecular platforms are scaffold-containing microdomains where key proteins associate to prominently influence cellular processes and behavior. Each component, by itself, is less effective, but when together with various scaffold proteins to form a platform, the components become more specific and efficient to convey the messages. This review article discusses the experimental evidence that supports the role of Thy-1/CD90 as a membrane-associated platform (ThyMAP).
dc.descriptionRegular 2015
dc.descriptionFONDECYT
dc.descriptionFONDECYT
dc.languageeng
dc.relationhandle/10533/111557
dc.relationhandle/10533/111541
dc.relationhandle/10533/108045
dc.relationhttps://doi.org/10.3389/fcell.2019.00132
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsinfo:eu-repo/semantics/article
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleThy-1/CD90 a Bidirectional and Lateral Signaling Scaffold
dc.titleFRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
dc.typeArticulo
dc.typeinfo:eu-repo/semantics/publishedVersion


Este ítem pertenece a la siguiente institución