Stage-specific role of interferon-gamma in experimental autoimmune encephalomyelitis and multiple sclerosis
Frontiers In Immunology
| dc.creator | Arellano-Lorca, Gabriel | |
| dc.creator | Ottum, Payton A | |
| dc.creator | Reyes, Lilian I | |
| dc.creator | Burgos, Paula Isabel | |
| dc.creator | Naves-Pichuante, Rodrigo Antonio | |
| dc.date | 2018-10-02T18:15:06Z | |
| dc.date | 2022-07-07T15:19:33Z | |
| dc.date | 2018-10-02T18:15:06Z | |
| dc.date | 2022-07-07T15:19:33Z | |
| dc.date | 2015 | |
| dc.date.accessioned | 2023-08-22T01:32:46Z | |
| dc.date.available | 2023-08-22T01:32:46Z | |
| dc.identifier | 1140049 | |
| dc.identifier | 1140049 | |
| dc.identifier | https://hdl.handle.net/10533/220770 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8306407 | |
| dc.description | The role of interferon (IFN)-gamma in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), has remained as an enigmatic paradox for more than 30 years. Several studies attribute this cytokine a prominent proinflammatory and pathogenic function in these pathologies. However, accumulating evidence shows that IFN-gamma also plays a protective role inducing regulatory cell activity and modulating the effector T cell response. Several innate and adaptive immune cells also develop opposite functions strongly associated with the production of IFN-gamma in EAE. Even the suppressive activity of different types of regulatory cells is dependent on IFN-gamma Interestingly, recent data supports a stage-specific participation of IFN-gamma in EAE providing a plausible explanation for previous conflicting results. In this review, we will summarize and discuss such literature, emphasizing the protective role of IFN-gamma on immune cells. These findings are fundamental to understand the complex role of IFN-gamma in the pathogenesis of these diseases and can provide basis for potential stage-specific therapy for MS targeting IFN-gamma-signaling or IFN-gamma producing immune cells. Keywords. Author Keywords:interferon-gamma; experimental autoimmune encephalomyelitis; multiple sclerosis; innate immunity; adaptive immunity; neuroinflammation . KeyWords Plus:EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; NATURAL-KILLER-CELLS; DELTA T-CELLS; MONOCLONAL-ANTIBODY TREATMENT; INVARIANT NKT CELLS; IFN-GAMMA; REGULATORY ROLE; NITRIC-OXIDE; TNF-ALPHA | |
| dc.language | eng | |
| dc.relation | instname: Conicyt | |
| dc.relation | reponame: Repositorio Digital RI2.0 | |
| dc.relation | info:eu-repo/grantAgreement//1140049 | |
| dc.relation | info:eu-repo/semantics/dataset/hdl.handle.net/10533/93477 | |
| dc.relation | https://www.ncbi.nlm.nih.gov/pubmed/26483787 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| dc.title | Stage-specific role of interferon-gamma in experimental autoimmune encephalomyelitis and multiple sclerosis | |
| dc.title | Frontiers In Immunology | |
| dc.type | Articulo | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion |