The Antigen Receptor as a Driver of B-Cell Lymphoma Development and Evolution
Hematology Latest Research and Clinical Advances
| dc.creator | Sepulveda, Julieta | |
| dc.creator | Seija, Noe | |
| dc.creator | Oppezzo, Pablo | |
| dc.creator | Navarrete, Marcelo | |
| dc.date | 2019-05-13T13:18:22Z | |
| dc.date | 2022-07-07T21:44:07Z | |
| dc.date | 2019-05-13T13:18:22Z | |
| dc.date | 2022-07-07T21:44:07Z | |
| dc.date | 2017 | |
| dc.date.accessioned | 2023-08-22T01:22:33Z | |
| dc.date.available | 2023-08-22T01:22:33Z | |
| dc.identifier | 11140542 | |
| dc.identifier | 11140542 | |
| dc.identifier | https://hdl.handle.net/10533/235149 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8305516 | |
| dc.description | The expression of a functional antigen receptor is necessary for cell survival of normal B lymphocytes and most B-cell neoplasms alike. When the genetic modifications of the B-cell receptor locus fail to produce a functional antigen receptor or result in deleterious mutations of a previously expressed receptor, the affected B cell will undergo apoptosis. The three physiological mechanisms that generate the B-cell receptor, VDJ recombination, somatic hypermutation, and class switch recombination, can induce double-strand DNA breaks and can specifically contribute to lymphomagenesis. On the other hand, the B-cell receptor activation and signaling pathways, which provide strong survival and proliferation signals to normal B cells, can support the growth and evolution of malignant lymphocytes. As a result, an otherwise structurally normal B-cell receptor can behave, from the functional perspective, as a true oncogene. In this chapter, we provide an in-depth discussion of the most recently discovered recurrent mechanisms involving the B-cell receptor in lymphoma pathogenesis. The discussion is structured around two major topics: (1) the genetic mechanisms that create a functional antigen receptor and their errors leading to oncogenic events, and (2) the pathogenic activation of the B-cell receptor signaling cascade. Finally, we will briefly comment on novel emerging therapies targeting the B-cell receptor at different levels. | |
| dc.format | application/pdf | |
| dc.relation | instname: Conicyt | |
| dc.relation | reponame: Repositorio Digital RI2.0 | |
| dc.relation | info:eu-repo/grantAgreement//11140542 | |
| dc.relation | info:eu-repo/semantics/dataset/hdl.handle.net/10533/93477 | |
| dc.relation | https://www.intechopen.com/books/hematology-latest-research-and-clinical-advances/the-antigen-receptor-as-a-driver-of-b-cell-lymphoma-development-and-evolution | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| dc.title | The Antigen Receptor as a Driver of B-Cell Lymphoma Development and Evolution | |
| dc.title | Hematology Latest Research and Clinical Advances | |
| dc.type | Articulo | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion |