Gestational Hypothyroxinemia Affects Its Offspring With a Reduced Suppressive Capacity Impairing the Outcome of the Experimental Autoimmune Encephalomyelitis

Frontiers In Immunology

dc.creatorHaensgen, Henny
dc.creatorAlbornoz, Eduardo
dc.creatorOpazo, María Cecilia
dc.creatorBugueño, Katherinne
dc.creatorJara-Fernández, Evelyn Liliana
dc.creatorBinzberger, Rebecca
dc.creatorRivero-Castillo, Tomás
dc.creatorVenegas-Salas, Luis F
dc.creatorSimon, Felipe
dc.creatorCabello-Verrugio, Tomás
dc.creatorElorza, Alvaro A
dc.creatorKalergis-Parra, Alexis Mikes
dc.creatorBueno, Susan M
dc.creatorRiedel, Claudia A
dc.date2019-08-28T17:15:21Z
dc.date2022-07-07T21:53:50Z
dc.date2019-08-28T17:15:21Z
dc.date2022-07-07T21:53:50Z
dc.date2018
dc.date.accessioned2023-08-21T23:31:37Z
dc.date.available2023-08-21T23:31:37Z
dc.identifier1150862
dc.identifier1150862
dc.identifierhttps://hdl.handle.net/10533/236520
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8295845
dc.descriptionHypothyroxinemia (Hpx) is a thyroid hormone deficiency (THD) condition highly frequent during pregnancy, which although asymptomatic for the mother, it can impair the cognitive function of the offspring. Previous studies have shown that maternal hypothyroidism increases the severity of experimental autoimmune encephalomyelitis (EAE), an autoimmune disease model for multiple sclerosis (MS). Here, we analyzed the immune response after EAE induction in the adult offspring gestated in Hpx. Mice gestated in Hpx showed an early appearance of EAE symptoms and the increase of all parameters of the disease such as: the pathological score, spinal cord demyelination, and immune cell infiltration in comparison to the adult offspring gestated in euthyroidism. Isolated CD4+CD25+ T cells from spleen of the offspring gestated in Hpx that suffer EAE showed reduced capacity to suppress proliferation of effector T cells (T-Eff) after being stimulated with anti-CD3 and anti-CD28 antibodies. Moreover, adoptive transfer experiments of CD4+CD25+ T cells from the offspring gestated in Hpx suffering EAE to mice that were induced with EAE showed that the receptor mice suffer more intense EAE pathological score. Even though, no significant differences were detected in the frequency of T-reg cells and IL-10 content in the blood, spleen, and brain between mice gestated in Hpx or euthyroidism, T cells CD4+CD25+ from spleen have reduced capacity to differentiate in vitro to Treg and to produce IL-10. Thus, our data support the notion that maternal Hpx can imprint the immune response of the offspring suffering EAE probably due to a reduced capacity to trigger suppression. Such "imprints" on the immune system could contribute to explaining as to why adult offspring gestated in Hpx suffer earlier and more intense EAE. Keywords. Author Keywords:hypothyroxinemia; T regulatory cells; multiple sclerosis; pregnancy; experimental autoimmune encephalomyelitis
dc.relationinstname: Conicyt
dc.relationreponame: Repositorio Digital RI2.0
dc.relationinfo:eu-repo/grantAgreement//1150862
dc.relationinfo:eu-repo/semantics/dataset/hdl.handle.net/10533/93477
dc.relationhttps://www.frontiersin.org/articles/10.3389/fimmu.2018.01257/full
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.titleGestational Hypothyroxinemia Affects Its Offspring With a Reduced Suppressive Capacity Impairing the Outcome of the Experimental Autoimmune Encephalomyelitis
dc.titleFrontiers In Immunology
dc.typeArticulo
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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