Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered
Journal Cell Communication and Signaling
| dc.creator | Contreras, Osvaldo | |
| dc.creator | Brandan-Siqués, Enrique Héctor | |
| dc.date | 2021-08-23T22:58:02Z | |
| dc.date | 2022-07-07T02:43:31Z | |
| dc.date | 2021-08-23T22:58:02Z | |
| dc.date | 2022-07-07T02:43:31Z | |
| dc.date | 2017 | |
| dc.date.accessioned | 2023-08-21T20:39:48Z | |
| dc.date.available | 2023-08-21T20:39:48Z | |
| dc.identifier | 1150106 | |
| dc.identifier | 1150106 | |
| dc.identifier | https://hdl.handle.net/10533/252187 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8279569 | |
| dc.description | PDGFR alpha regulates several cellular processes, and exacerbated PDGF signaling cause fibrosis in different tissues. Different research groups have shown that fibro/adipogenic progenitors (FAPs) are responsible for pathological fibrosis found in skeletal muscle disorders. Rando's Lab describes that an intronic polyadenylation of Pdgfra regulates FAPs activity, and therefore fibrosis. This discovery opens a new potential target for treating fibrosis. Keywords. Author Keywords:Fibrosis | |
| dc.description | PDGFR alpha | |
| dc.description | Fibro/adipogenic progenitors | |
| dc.description | Muscle regeneration | |
| dc.description | Polyadenylation KeyWords Plus:CONNECTIVE-TISSUE FIBROBLASTS | |
| dc.description | MUSCLE FIBROSIS | |
| dc.description | SKELETAL-MUSCLE | |
| dc.description | SATELLITE CELLS | |
| dc.description | PDGFR-ALPHA | |
| dc.description | MYOGENESIS | |
| dc.description | DYSTROPHY | |
| dc.description | INJURY | |
| dc.description | Regular 2015 | |
| dc.description | FONDECYT | |
| dc.description | FONDECYT | |
| dc.language | eng | |
| dc.relation | handle/10533/111557 | |
| dc.relation | handle/10533/111541 | |
| dc.relation | handle/10533/108045 | |
| dc.relation | http://www.observatoriodocente.cl/download.php?file=recursos/Perfiles_Motivacionales.pdf | |
| dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| dc.rights | info:eu-repo/semantics/article | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.title | Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered | |
| dc.title | Journal Cell Communication and Signaling | |
| dc.type | Articulo | |
| dc.type | info:eu-repo/semantics/publishedVersion |