Validación del volumen plaquetario medio como predictor de severidad de preeclampsia
Fecha
2023-06-09Autor
Delgado Suárez, Diana Patricia
Institución
Resumen
Preeclampsia is a serious complication that can occur during pregnancy, and is associated
with considerable maternal and fetal morbidity and mortality. Therefore, laboratory tests that
allow its prediction are undoubtedly of great support in obstetric practice. The objective of this
study was to determine the validity of the mean platelet volume as a predictor of the severity
of preeclampsia in patients treated at the Vicente Corral Moscoso Hospital, in the period 2019.
This is a diagnostic test valida- tion study. 387 pregnant women who met the inclusion criteria
were included. For the diagnosis of severity of preeclampsia, the protein/creatinine index was
applied. To determine the validity of the mean platelet volume in severity, the cut-off point for
this population of >11.65 fl was used, obtained using the Youden Index. Descriptive statis- tics
and sensitivity, specificity, predictive va- lues, ROC curve and Fagan’s nanogram were
applied. Mean platelet volume did not prove to be a test with optimal predictive capacity for
the severity of preeclamptic symptoms, since the value of the area under the cur- ve was 0.44
(95% CI = 0.38-0.50), however,the proportion of women confirmed as mild preeclamptic by
the negative result of the test (≤ 11.65 fL) was 87.92% (95% CI = 82.35 – 93.49). The pre-test
probability corresponds to the prevalence of severe preeclampsia of 61% with a likelihood
ratio of 1.89, however, with a positive result of MPV (>11.65), the frequency of presentation of
severe preeclampsia increased to 75%.