The present work leads to the creation of a clinical case with the topic NURSING CARE PROCESS IN PRETERM NEWBORN WITH NECROTIZING ENTEROCOLITIS. This case was presented at the Alfredo Noboa Montenegro General Hospital in the city of Guaranda de la Parroquia Veintimilla.To carry out the following clinical case, a diagnostic methodology was used where the patient's clinical history is known, the formulation of presumptive, differential, definitive and nursing data, follow-up and observations. In addition, the theoretical framework is deepened where information about the care of the newborn with necrotizing enterocolitis is investigated. Necrotizing enterocolitis continues to exist as one of the major undetermined difficulties in neonatal care. Despite the evolution in neonatal intensive care, it remains a dangerous disease. With the increase in survival of very low birth weight newborns, it emerges as a transcendental origin of neonatal mortality, being the most common cause of severe gastrointestinal disturbance in Neonatal Intensive Care Units. It affects about 10% of newborns weighing less than 1500g, with mortality rates of 50% or more, depending on the difficulty. Although it is true it is common in premature newborns, it can also be observed in term babies. Despite the massive inquiries on the subject over the last 30 years, its cause remains unknown. Early discovery through nursing assessment is important for prompt treatment. Clinical skills by the neonatal nurse or nurse are essential because the clinical signs of necrotizing enterocolitis can be minor or fatal.The present work leads to the creation of a clinical case with the topic NURSING CARE PROCESS IN PRETERM NEWBORN WITH NECROTIZING ENTEROCOLITIS. This case was presented at the Alfredo Noboa Montenegro General Hospital in the city of Guaranda de la Parroquia Veintimilla.To carry out the following clinical case, a diagnostic methodology was used where the patient's clinical history is known, the formulation of presumptive, differential, definitive and nursing data, follow-up and observations. In addition, the theoretical framework is deepened where information about the care of the newborn with necrotizing enterocolitis is investigated. Necrotizing enterocolitis continues to exist as one of the major undetermined difficulties in neonatal care. Despite the evolution in neonatal intensive care, it remains a dangerous disease. With the increase in survival of very low birth weight newborns, it emerges as a transcendental origin of neonatal mortality, being the most common cause of severe gastrointestinal disturbance in Neonatal Intensive Care Units. It affects about 10% of newborns weighing less than 1500g, with mortality rates of 50% or more, depending on the difficulty. Although it is true it is common in premature newborns, it can also be observed in term babies. Despite the massive inquiries on the subject over the last 30 years, its cause remains unknown. Early discovery through nursing assessment is important for prompt treatment. Clinical skills by the neonatal nurse or nurse are essential because the clinical signs of necrotizing enterocolitis can be minor or fatal.El presente trabajo da lugar a la creación de un caso clínico con el tema PROCESO DE ATENCIÓN DE ENFERMERÍA EN NEONATO PRETERMINO CON ENTEROCOLITIS NECROTIZANTE. Este caso se presentó en el Hospital General Alfredo Noboa Montenegro de la ciudad de Guaranda de la Parroquia Veintimilla. Para realizar el siguiente caso clínico se usó una metodología del diagnóstico donde se conoce la historia clínica del paciente, la formulación de datos presuntiva, diferencial, definitiva y enfermero, seguimiento y observaciones. Además se profundiza el marco teórico donde se indaga información acerca de cuidados al recién nacido con enterocolitis necrotizante. La enterocolitis necrotizante sigue existiendo como uno de las principales dificultades no determinadas en la atención neonatal. A pesar de la evolución en el cuidado intensivo neonatal, subsiste como una enfermedad peligrosa. Con el aumento en la sobrevida de los recién nacidos de muy bajo peso, surge como una procedencia trascendental de mortalidad neonatal, siendo la causa más habitual de alteración gastrointestinal severa en las Unidades De Cuidados Intensivos Neonatales. Altera a cerca de un 10% de los recién nacidos que pesan menos de 1500gr, con tasas de mortalidad del 50% o más, dependiendo de la dificultad. Si bien es cierto es habitual en recién nacidos prematuros, además puede ser observado en bebes de término. A pesar de las multitudinarias indagaciones en el tema durante los últimos 30 años su causa sigue siendo desconocida. El descubrimiento precoz a través de la valoración de enfermería es importante para el tratamiento oportuno. Son indispensables las habilidades clínicas por la enfermera o enfermero neonatal debido a que los signos clínicos de enterocolitis necrotizante pueden ser menudos o fatales.