Objective. Evaluate the psychological effects of social isolation (post-traumatic stress symptoms) associated with the global pandemic situation and the possible association with positive psychological functioning. Method. The design was a cross-sectional study with 440 participants between 18 and 65 years old (M = 35.25) selected through convenience sampling. Sociodemographic, coexistence and occupation data were collected. The information was collected online, between April and July 2020. A descriptive and comparative analysis of the variables was carried out. Results. A relationship between Social Isolation and Post Traumatic Stress Symptoms was observed. Positive psychological functioning was inversely correlated with social isolation and post-traumatic stress symptoms, which are more evident in the middle and older age ranges (36-50 and 51-65). Positive psychological functioning showed higher levels in the 51-65 age group and in participants from the interior of the country. Symptoms of anxiety and depression were greater in young people (18-25 years old), women, city residents, and people living with their parents. These data can inform treatment strategies that attempt to reduce the psychological symptoms of COVID-19 isolation, based on psychological resources.Objetivo. Evaluar los efectos psicológicos del aislamiento social (síntomas de estrés postraumático) asociados a la situación mundial de pandemia y la posible asociación con el funcionamiento psicológico positivo. Método. Se realizó un estudio transversal con 440 participantes entre 18 y 65 años (M = 35.25), a través de un muestreo por conveniencia. Se recogieron datos sociodemográficos, convivencia y ocupación. La información se recogió en formato en línea, entre abril y julio de 2020. Se realizó un análisis descriptivo y comparativo de las variables. Resultados. Se observó una relación entre Aislamiento Social y Síntomas de estrés post traumáticos. El funcionamiento psicológico positivo se correlacionó de manera inversa con el aislamiento social y los síntomas de estrés post traumático, los que son más evidentes en las franjas de edad intermedia y mayor (36-50 y 51-65). El funcionamiento psicológico positivo mostró niveles más elevados en el grupo de 51-65 años y en participantes del interior del país. Los síntomas de ansiedad y depresión fueron mayores en jóvenes (de 18-25 años), mujeres, residentes de ciudad y personas que viven con sus padres. Estos datos pueden aportar a las estrategias de tratamientos que intenten reducir los síntomas psicológicos del aislamiento por COVID-19, basado en los recursos psicológicos.Objective. Evaluate the psychological effects of social isolation (post-traumatic stress symptoms) associated with the global pandemic situation and the possible association with positive psychological functioning. Method. The design was a cross-sectional study with 440 participants between 18 and 65 years old (M = 35.25) selected through convenience sampling. Sociodemographic, coexistence and occupation data were collected. The information was collected online, between April and July 2020. A descriptive and comparative analysis of the variables was carried out. Results. A relationship between Social Isolation and Post Traumatic Stress Symptoms was observed. Positive psychological functioning was inversely correlated with social isolation and post-traumatic stress symptoms, which are more evident in the middle and older age ranges (36-50 and 51-65). Positive psychological functioning showed higher levels in the 51-65 age group and in participants from the interior of the country. Symptoms of anxiety and depression were greater in young people (18-25 years old), women, city residents, and people living with their parents. These data can inform treatment strategies that attempt to reduce the psychological symptoms of COVID-19 isolation, based on psychological resources.