Congenital and acquired toxoplasmosis: Diversity and role of antibodies in different compartments of the host.

dc.creatorMARIA DOLORES CORREA BELTRAN
dc.creatorIRMA CAÑEDO SOLARES
dc.creatorLUZ BELINDA ORTIZ ALEGRIA
dc.creatorHERIBERTO CABALLERO ORTEGA
dc.creatorCLAUDIA PATRICIA RICO TORRES
dc.date2007
dc.date.accessioned2023-07-25T16:15:47Z
dc.date.available2023-07-25T16:15:47Z
dc.identifier10.1111/j.1365-3024.2007.00982.x
dc.identifierhttp://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/3123
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7805160
dc.descriptionThe apicomplexan parasite Toxoplasma gondii is remarkable in several aspects, since it is a protozoan that infects most nucleated cells in many warm-blooded animals, worldwide. Although the cellular immune response against T. gondii is critical for infection control, antibodies may either enhance or block protective mechanisms, and even mediate immunological damage, directly or indirectly. Since cytokines regulate the class/subclass switch, antibodies may also be the biomarkers of protective or pathological cellular immune events. There is a scientific and clinical interest in the presence of natural and autoreactive antibodies, as well as in the 'chronic' immunoglobulin M (IgM) response and the post-treatment 'rebound'. Another interesting aspect is compartmentalization; certain immunoglobulins may uniquely be found in specific host fluids. Local synthesis has been demonstrated, but antibodies may also traverse several cell layers, like the blood-brain and haemato-ocular barriers, and the placenta. In some instances, Fc receptors (FcRs) facilitate transport and may even have a concentrator effect, which can be related to resistance or pathology. These aspects of the humoral response against T. gondii are reviewed in the present paper. © 2007 The Authors.
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceParasite Immunology 29(12):651 - 660
dc.subjectinfo:eu-repo/classification/cti/3
dc.subjectAnticuerpos antiprotozoarios - Inmunología
dc.subjectToxoplasmosis - Inmunología
dc.subjectToxoplasmosis animal - Inmunología
dc.subjectToxoplasmosis congénita - Inmunología
dc.subjectAntibodies, protozoan - immunology
dc.subjectToxoplasmosis - Immunology
dc.subjectToxoplasmosis, animal - Immunology
dc.subjectToxoplasmosis, congenital - Immunology
dc.subjectAntibodies
dc.subjectCompartments
dc.subjectComplement
dc.subjectCytokine regulation
dc.subjectToxoplasma gondii
dc.subjectToxoplasmosis
dc.titleCongenital and acquired toxoplasmosis: Diversity and role of antibodies in different compartments of the host.
dc.typeinfo:eu-repo/semantics/article


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