Antiviral and antiproliferative potential of marine organisms from the Yucatan Peninsula, Mexico

dc.contributorJUDITH BERASTEGUI CABRERA
dc.contributorBASTEIN CAUTAIN
dc.contributorFERNANDO REYES
dc.contributorGERONIMO PACHON
dc.contributorPATRICIA GOMEZ LOPEZ
dc.contributorJAIME RODRIGUEZ GONZALEZ
dc.contributorCARLOS JIMENEZ GONZALEZ
dc.contributorJAVIER SANCHEZ CESPEDES
dc.creatorHAROLD OSWALDO VILLEGAS HERNANDEZ
dc.creatorDAWRIN JESUS PECH PUCH
dc.creatorMAR ANABEL PEREZ POVEDANO
dc.creatorSERGIO GUILLEN HERNANDEZ
dc.date2020-08-20
dc.date.accessioned2023-07-25T14:00:08Z
dc.date.available2023-07-25T14:00:08Z
dc.identifierhttp://redi.uady.mx:8080/handle/123456789/5182
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7798790
dc.descriptionViral infections are one of the main human health problems in recent decades and the cancer remains one of the most lethal diseases worldwide. The development of new antiviral drugs for the treatment of human adenovirus (HAdV) infections continues to be a challenging goal for medicinal chemistry. There is no specific antiviral drug approved to treat infections caused by HAdV so far and the off-label treatments currently available show great variability in their effectiveness. In relation to cancer, most of the available drugs are designed to act on specific targets by altering the activity of involved transporters and genes. Taking into account the high antiviral and antiproliferative activity against tumor cell lines displayed by some marine natural products reported in the literature, sixty five marine organisms were selected: 51 sponges (Porifera), 13 ascidians (Chordata), and 1 gorgonian (Cnidaria), collected from Yucatan Peninsula, Mexico, to evaluate their antiviral activity against human adenovirus type 5 (HAdV5) and their anticancer properties against five human tumor cell lines, namely human lung carcinoma (A549), human skin melanoma (A2058), hepatocyte carcinoma (HepG2), breast adenocarcinoma (MCF7), and pancreas carcinoma (MiaPaca-2). Eleven extracts displayed anti-HAdV activity being the organic extracts of Dysidea sp., Agelas citrina, Chondrilla sp., Spongia tubulifera, and Monanchora arbuscula the five most active ones. On the other hand, 24 extracts showed antiproliferative activity against at least one tumor cell line, being the extracts of the ascidian Eudistoma amanitum and the sponge Haliclona (Rhizoniera) curacaoensis the most active ones. This work constitutes the first wide antiviral and antiproliferative screening report of extracts from the marine sponges, ascidians, and a gorgonian collected from the Yucatan Peninsula, Mexico.
dc.formatapplication/pdf
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceurn:issn:2296-7745
dc.subjectinfo:eu-repo/classification/cti/2
dc.subjectinfo:eu-repo/classification/cti/3
dc.subjectAntiviral
dc.subjectAntiproliferative
dc.subjectYucatan Peninsula
dc.subjectMarine organisms extracts
dc.subjectSponges
dc.subjectAscidians
dc.subjectGorgonian
dc.titleAntiviral and antiproliferative potential of marine organisms from the Yucatan Peninsula, Mexico
dc.typeinfo:eu-repo/semantics/article
dc.coverageGeneración de conocimiento
dc.audienceresearchers


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