Anesthetic evaluation of a novel phospholipid-free 1% propofol microemulsion formulation in dogs

dc.contributorMARIA BERNAD BERNAD
dc.creatorEDUARDO GUTIERREZ BLANCO
dc.creatorITZCOATL FELIPE AQUINO DIAZ
dc.creatorLUIS OCAMPO CAMBEROS
dc.creatorLILIA GUTIERREZ OLVERA
dc.creatorHECTOR SALVADOR SUMANO LOPEZ
dc.date2019-07-31
dc.date.accessioned2023-07-25T13:59:33Z
dc.date.available2023-07-25T13:59:33Z
dc.identifierhttp://redi.uady.mx:8080/handle/123456789/4939
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7798547
dc.descriptionA novel four-week stable experimental formulation of propofol lacking phospholipids (PMICRO) was assessed as an anesthetic agent in dogs and compared to the customary preparation of propofol that contains phospholipids (PMACRO). Forty healthy mixed-breed dogs were included in this study and randomly assigned (blocking by sex and age), to receive 5 mg/kg of one of these two pharmaceutical propofol preparations, by intravenous injection. Basal and post anesthetic blood biochemical parameters were measured. Also, cardiovascular and respiratory rates were recorded. Onset, duration and recovery from anesthesia, were documented as well. Overall, IV administration of PMICRO induces a short duration anesthesia with rapid recovery in a similar manner to anesthesia achieved with the customary propofol preparation (PMACRO). Because PMICRO lacks phospholipids, it may allow a longer storage time, decreasing the likeliness of accidental administration of contaminated propofol.
dc.formatapplication/pdf
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceurn:issn:2448-6760
dc.subjectinfo:eu-repo/classification/cti/2
dc.subjectinfo:eu-repo/classification/cti/3
dc.subjectAnesthesia
dc.subjectDog
dc.subjectMicroemulsion
dc.subjectPhospholipid-free
dc.subjectPropofol
dc.titleAnesthetic evaluation of a novel phospholipid-free 1% propofol microemulsion formulation in dogs
dc.typeinfo:eu-repo/semantics/article
dc.coverageInvestigación aplicada
dc.audienceresearchers


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