Replication of obesity and diabetes-related SNP associations in individuals from Yucatán, México

dc.contributorEDNA J. NAVA GONZALEZ
dc.contributorVENKATA SAROJA VORUGANTI
dc.contributorJACK W. KENT
dc.contributorKARIN HAACK
dc.contributorFERNANDA MOLINA SEGUI
dc.contributorESTHER C. GALLEGOS CABRIALES
dc.contributorSHELLEY A. COLE
dc.contributorMARGUERITE J. MEZZLES
dc.contributorANTHONY G. COMUZZIE
dc.creatorVICTOR MANUEL HERNANDEZ ESCALANTE
dc.creatorHUGO ANTONIO LAVIADA MOLINA
dc.creatorJUAN CARLOS LOPEZ ALVARENGA
dc.creatorRAUL ADOLFO DE JESUS BASTARRACHEA SOSA
dc.date2014-11-18
dc.date.accessioned2023-07-25T13:52:29Z
dc.date.available2023-07-25T13:52:29Z
dc.identifierhttp://redi.uady.mx:8080/handle/123456789/1927
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7795550
dc.descriptionThe prevalence of type 2 diabetes (T2D) is rising rapidly and in Mexicans is ~19%. T2D is affected by both environmental and genetic factors. Although specific genes have been implicated in T2D risk few of these findings are confirmed in studies of Mexican subjects. Our aim was to replicate associations of 39 single nucleotide polymorphisms (SNPs) from 10 genes with T2D-related phenotypes in a community-based Mexican cohort. Unrelated individuals (n = 259) living in southeastern Mexico were enrolled in the study based at the University of Yucatan School of Medicine in Merida. Phenotypes measured included anthropometric measurements, circulating levels of adipose tissue endocrine factors (leptin, adiponectin, pro-inflammatory cytokines), and insulin, glucose, and blood pressure. Association analyses were conducted by measured genotype analysis implemented in SOLAR, adapted for unrelated individuals. SNP Minor allele frequencies ranged from 2.2 to 48.6%. Nominal associations were found for CNR1, SLC30A8, GCK, and PCSK1 SNPs with systolic blood pressure, insulin and glucose, and for CNR1, SLC30A8, KCNJ11, and PCSK1 SNPs with adiponectin and leptin (p < 0.05). P-values greater than 0.0014 were considered significant. Association of SNPs rs10485170 of CNR1 and rs5215 of KCNJ11 with adiponectin and leptin, respectively, reached near significance (p = 0.002). Significant association (p = 0.001) was observed between plasma leptin and rs5219 of KCNJ11.
dc.formatapplication/pdf
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceurn:issn:1664-8021
dc.subjectinfo:eu-repo/classification/cti/3
dc.subjectSingle Nucleotide Polymorphisms (SNP)
dc.subjectAssociation analysis
dc.subjectMinor allele frequency
dc.subjectType 2 diabetes
dc.subjectObesity
dc.titleReplication of obesity and diabetes-related SNP associations in individuals from Yucatán, México
dc.typeinfo:eu-repo/semantics/article
dc.coverageGeneración de conocimiento
dc.audienceresearchers


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