dc.creatorVALERI DOMINGUEZ VILLEGAS
dc.creatorMA LUISA DEL CARMEN GARDUÑO RAMIREZ
dc.date2023
dc.date.accessioned2023-07-25T12:47:39Z
dc.date.available2023-07-25T12:47:39Z
dc.identifier1999-4923
dc.identifierhttp://riaa.uaem.mx/handle/20.500.12055/3919
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7792532
dc.descriptionThe increasing number of skin cancer cases worldwide and the adverse side effects of current treatments have led to the search for new anticancer agents. In this present work, the anticancer potential of the natural flavanone 1, extracted from Eysenhardtia platycarpa, and four flavanone derivatives 1a–d obtained by different reactions from 1 was investigated by an in silico study and through cytotoxicity assays in melanoma (M21), cervical cancer (HeLa) cell lines and in a non-tumor cell line (HEK-293). The free compounds and compounds loaded in biopolymeric nanoparticles (PLGA NPs 1, 1a–d) were assayed. A structure–activity study (SAR) was performed to establish the main physicochemical characteristics that most contribute to cytotoxicity. Finally, ex vivo permeation studies were performed to assess the suitability of the flavanones for topical administration. Results revealed that most of the studied flavanones and their respective PLGA NPs inhibited cell growth depending on the concentration; 1b should be highlighted. The descriptors of the energetic factor were those that played a more important role in cellular activity. PLGA NPs demonstrated their ability to penetrate (Qp of 17.84−118.29 µg) and be retained (Qr of 0.01−1.44 g/gskin/cm2) in the skin and to exert their action for longer. The results of the study suggest that flavanones could offer many opportunities as a future anticancer topical adjuvant treatment.
dc.languageeng
dc.publisherMDPI
dc.relationPharmaceutics
dc.relation6
dc.relation15
dc.relationhttps://www.mdpi.com/1999-4923/15/6/1632?fbclid=IwAR1bXoCR0tldbty14sS5Va3Jo690PyrMjZxk5GVwoxAuWYokeQqA9m9r_ZA
dc.relationinfo:eu-repo/semantics/altIdentifier/issn/1999-4923
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by/4.0
dc.subjectinfo:eu-repo/classification/cti/2
dc.subjectinfo:eu-repo/classification/cti/23
dc.subjectEysenhardtia platycarpa, flavanone derivatives, polymeric nanoparticles, cytotoxicity activity
dc.titleIn Vitro Approaches to Explore the Anticancer Potential of One Natural Flavanone and Four Derivatives Loaded in Biopolymeric Nanoparticles for Application in Topical Delivery Treatments
dc.typeinfo:eu-repo/semantics/article
dc.coverageMEX
dc.audienceresearchers
dc.audienceteachers


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