Antibacterial Activity of Crude Extract and Purified Acetogenins from Annona muricata Seeds

dc.creatorAguilar Hernández, Gabriela
dc.creatorLópez Romero, Brandon A
dc.creatorPérez Larios, Alejandro
dc.creatorRuvalcaba Gómez, José M
dc.creatorCastellanos Huerta, Inkar
dc.creatorTellez Isaias, Guillermo
dc.creatorPetrone García, Victor M
dc.creatorAnaya Esparza, Luis Miguel
dc.creatorMontalvo González, Efigenia
dc.date2023-06-20T19:46:49Z
dc.date2023-06-20T19:46:49Z
dc.date2023-01
dc.date.accessioned2023-07-21T21:46:38Z
dc.date.available2023-07-21T21:46:38Z
dc.identifierAguilar-Hernández G, López-Romero BA, Pérez-Larios A, Ruvalcaba-Gómez JM, Castellanos-Huerta I, Tellez-Isaias G, Petrone-García VM, Anaya-Esparza LM, Montalvo-González E. Antibacterial Activity of Crude Extract and Purified Acetogenins from Annona muricata Seeds. Applied Sciences. 2023; 13(1):558. https://doi.org/10.3390/app13010558
dc.identifier2076-3417
dc.identifierhttps://doi.org/10.3390/app13010558
dc.identifierhttp://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1526
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7752992
dc.descriptionArtículo
dc.descriptionCurrently, several biological activities are attributed to the acetogenins (ACGs) of Annonaceae (including Annona muricata); among these is antimicrobial activity. The main focus of this experiment was to evaluate the antimicrobial effect of the crude extract (CE) and purified acetogenins (P-ACGs) from the endosperm of A. muricata seeds using agar disk diffusion, lethality, sub-lethal, and potential damage membrane tests against Gram-positive and Gram-negative microorganisms. According to the results, P-ACGs present the highest antibacterial effect (12.5–4000 µg/mL) against Enterococcus faecalis (11–15.67 mm), Listeria monocytogenes (12–18 mm), Aeromonas hydrophila (10.33–11.67 mm), Bulkholderia cenocepacia (11–12 mm), and Salmonella paratiphy (11–15.67 mm), and a minimum inhibitory concentration ranging from 0.009 to 12.50 µg/mL. Measurement of the membrane potential shows that, in the presence of P-ACGs, the number of viable cells is reduced, with a significant logarithmic reduction observed (0.38, 1.27, and 1.81 CFU/mL) and a significant sub-lethal lesion (57.78, 96.14, and 98.42%) in Escherichia coli, E. faecalis, and L. monocytogenes, respectively. According to this study, the results demonstrate that P-ACGs from A. muricata seeds are potent and effective antibacterial compounds with potential pharmaceutical applications.
dc.languageen
dc.publisherMultidisciplinary Digital Publishing Institute
dc.relationApplied Sciences;2023, Vol. 13 (1), 558
dc.subjectA. muricata
dc.subjectseeds
dc.subjectacetogenins
dc.subjectnatural extracts
dc.subjectantimicrobial activity
dc.titleAntibacterial Activity of Crude Extract and Purified Acetogenins from Annona muricata Seeds
dc.typeArticle


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