Signaling Pathways Involved in Myocardial Ischemia–Reperfusion Injury and Cardioprotection: A Systematic Review of Transcriptomic Studies in Sus scrofa

dc.creatorSalazar González, Héctor
dc.creatorGutiérrez Mercado, Yanet Karina
dc.creatorMunguia Galaviz, Francisco Javier
dc.creatorEchavarría, Raquel
dc.date2023-02-17T19:18:44Z
dc.date2023-02-17T19:18:44Z
dc.date2022-05
dc.date.accessioned2023-07-21T21:46:23Z
dc.date.available2023-07-21T21:46:23Z
dc.identifier: Salazar-Gonzalez, H.; Gutierrez-Mercado, Y.K.; Munguia-Galaviz, F.J.; Echavarria, R. Signaling Pathways Involved in Myocardial Ischemia–Reperfusion Injury and Cardioprotection: A Systematic Review of Transcriptomic Studies in Sus scrofa. J. Cardiovasc. Dev. Dis. 2022, 9, 132. https:// doi.org/10.3390/jcdd9050132
dc.identifier2308-3425
dc.identifierhttps:// doi.org/10.3390/jcdd9050132
dc.identifierhttp://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1489
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7752957
dc.descriptionArtículo
dc.descriptionAbstract Myocardial damage in acute myocardial infarctions (AMI) is primarily the result of ischemia–reperfusion injury (IRI). Recognizing the timing of transcriptional events and their modulation by cardioprotective strategies is critical to address the pathophysiology of myocardial IRI. Despite the relevance of pigs for translational studies of AMI, only a few have identified how transcriptomic changes shape cellular signaling pathways in response to injury. We systematically reviewed transcriptomic studies of myocardial IRI and cardioprotection in Sus scrofa. Gene expression datasets were analyzed for significantly enriched terms using the Enrichr analysis tool, and statistically significant results (adjusted p-values of <0.05) for Signaling Pathways, Transcription Factors, Molecular Functions, and Biological Processes were compared between eligible studies to describe how these dynamic changes transform the myocardium from an injured and inflamed tissue into a scar. Then, we address how cardioprotective interventions distinctly modulate the myocardial transcriptome and discuss the implications of uncovering gene regulatory networks for cardiovascular pathologies and translational applications.
dc.languageen
dc.publisherMDPI. International Journal of Environmental Research and Public Health
dc.relationJ. Cardiovasc. Dev. Dis.;2022, 9 (5), 132.
dc.subjectmyocardial ischemia
dc.subjectcardioprotection
dc.subjecttranscriptomics
dc.subjectsignaling pathways
dc.subjectRNA-seq
dc.subjectmicroarrays
dc.subjectswine
dc.titleSignaling Pathways Involved in Myocardial Ischemia–Reperfusion Injury and Cardioprotection: A Systematic Review of Transcriptomic Studies in Sus scrofa
dc.typeArticle


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