Ep-CAM (MOC-31) expression in tooth germ and ameloblastoma

Derderian N, Pereira-Prado V, Hernandez M, Isiordia-Espinoza M, Arocena M, González-González R, Tremillo-Maldonado O, Meleti M, Molina-Frechero N, Bologna-Molina R.

dc.creatorDerderian, Nathalie
dc.creatorPereira Prado, Vanesa
dc.creatorHernández, Marcela
dc.creatorIsiordia Espinoza, Mario Alberto
dc.creatorArocena, Miguel
dc.creatorGonzález González, Rogelio
dc.creatorTremillo Maldonado, Omar
dc.creatorMeleti, Marco
dc.creatorMolina Frechero, Nelly
dc.creatorBologna Molina, Ronell
dc.date2023-02-13T18:37:37Z
dc.date2023-02-13T18:37:37Z
dc.date2022-09
dc.date.accessioned2023-07-21T21:46:15Z
dc.date.available2023-07-21T21:46:15Z
dc.identifierDerderian N, Pereira-Prado V, Hernandez M, Isiordia-Espinoza M, Arocena M, González-González R, Tremillo-Maldonado O, Meleti M, Molina-Frechero N, Bologna-Molina R. Ep-CAM (MOC-31) expression in tooth germ and ameloblastoma. Med Oral Patol Oral Cir Bucal. 2022 Sep 1;27(5):e403-e409. doi: 10.4317/medoral.25145. PMID: 35975801; PMCID: PMC9445613.
dc.identifier1698-6946 online
dc.identifierdoi: 10.4317/medoral.25145. PMID: 35975801
dc.identifier1698-4447 print
dc.identifierhttp://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1470
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7752938
dc.descriptionArtículo
dc.descriptionAbstract Background: Ep-CAM, a transmembrane glycoprotein expressed in most epithelium in normal conditions, has diverse roles in these tissues, including in cell adhesion, proliferation, differentiation, cell cycle regulation, migration and intracellular signaling. It is also over-expressed in most malignant neoplasia, participating in the initiation, progression, and metastatic dissemination of the tumor. The expression and roles of this protein in oral neoplasia, particularly in odontogenic tumors, remain unestablished. The objective of this study consisted in analyzing the expression of this protein in ameloblastoma and tooth germ. Material and methods: Ep-CAM (MOC-31) expression was evaluated by immunohistochemistry in tooth germs (TG) (n = 16) ameloblastomas (AM) (n = 60) and 2 ameloblastic carcinomas. Sections were visualized in their totality with an optical microscope, and positivity observed in cell membrane and cytoplasm was graded according to the following semi-quantitative scale: Neg, "essentially unstained", for negative sections or staining <5% of cells; + for staining of 5-50% of cells; ++ for staining >50% of cells. Results: Most tooth germs expressed MOC-31 (81.3%), strong staining was observed both in the inner epithelium of the enamel organ and in the adjacent stellate reticulum. 16.7% of the AM cases showed MOC-31 expression, the immunoexpression expression was diffuse at the cytoplasmic and membrane level. The only two cases of ameloblastic carcinoma included were strong positive to MOC-31. No correlation was observed between protein expression and gender, age, clinical variants, or histological subtypes. Conclusions: Overexpression was found in TG and ameloblastic carcinoma compared to AM; further studies with different experimental strategies are suggested to clarify the biological significance of this finding.
dc.languageen
dc.publisherPubMed
dc.relationMed Oral Patol Oral Cir Bucal;022 Sep 1;27(5):e403-e409.
dc.subjecttooth germ
dc.subjectameloblastoma
dc.subjectEp-CAM
dc.subjectMOC-31
dc.subjectimmunohistochemistry
dc.titleEp-CAM (MOC-31) expression in tooth germ and ameloblastoma
dc.titleDerderian N, Pereira-Prado V, Hernandez M, Isiordia-Espinoza M, Arocena M, González-González R, Tremillo-Maldonado O, Meleti M, Molina-Frechero N, Bologna-Molina R.
dc.typeArticle


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