Extraction of Acetogenins Using Thermosonication-Assisted Extraction from Annona muricata Seeds and Their Antifungal Activity

dc.creatorLópez Romero, Brandon Alexis
dc.creatorLuna Bárcenas, Gabriel
dc.creatorGarcía Magaña, María de Lourdes
dc.creatorAnaya Esparza, Luis Miguel
dc.creatorZepeda Vallejo, Luis Gerardo
dc.creatorLópez García, Ulises Miguel
dc.creatorOrtiz Basurto, Rosa Isela
dc.creatorAguilar Hernández, Gabriela
dc.creatorPérez Larios, Alejandro
dc.creatorMontalvo González, Efigenia
dc.date2022-10-11T16:40:28Z
dc.date2022-10-11T16:40:28Z
dc.date2022-09
dc.date.accessioned2023-07-21T21:46:02Z
dc.date.available2023-07-21T21:46:02Z
dc.identifierLópez-Romero, B.A.; Luna-Bárcenas, G.; García-Magaña, M.d.L.; Anaya-Esparza, L.M.; Zepeda-Vallejo, L.G.; López-García, U.M.; Ortiz-Basurto, R.I.; Aguilar-Hernández, G.; Pérez-Larios, A.; Montalvo-González, E. Extraction of Acetogenins Using Thermosonication-Assisted Extraction from Annona muricata Seeds and Their Antifungal Activity. Molecules 2022, 27, 6045. https:// doi.org/10.3390/molecules27186045
dc.identifier1420-3049
dc.identifierhttps:// doi.org/10.3390/molecules27186045
dc.identifierhttp://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1439
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7752908
dc.descriptionArtículo
dc.descriptionThe objective of this work was to find the optimal conditions by thermosonication-assisted extraction (TSAE) of the total acetogenin content (TAC) and yield from A. muricata seeds, assessing the effect of the temperature (40, 50, and 60 ◦C), sonication amplitude (80, 90, and 100%), and pulse-cycle (0.5, 0.7, and 1 s). In addition, optimal TSAE conditions of acetogenins (ACGs) were compared with extraction by ultrasound at 25 ◦C and the soxhlet method measuring TAC and antioxidant capacity. Moreover, solubility and identification of isolated ACGs were performed. Furthermore, the antifungal activity of ACGs crude extract and isolated ACGs was evaluated. Optimal TSAE conditions to extract the highest TAC (35.89 mg/g) and yield (3.6%) were 50 ◦C, 100% amplitude, and 0.5 s pulse-cycle. TSAE was 2.17-fold and 15.60-fold more effective than ultrasound at 25 ◦C and the Soxhlet method to extract ACGs with antioxidant capacity. Isolated ACGs were mostly soluble in acetone and methanol. Seven ACGs were identified, and pseudoannonacin was the most abundant. The inhibition of Candida albicans, Candida krusei, and Candida tropicalis was higher from isolated ACGs than crude extract. TSAE was effective to increase the yield in the ACGs extraction from A. muricata seeds and these ACGs have important antifungal activity.
dc.languageen
dc.publisherMDPI
dc.relationMolecules;2022, 27(18), 6045
dc.subjectA. muricata seeds
dc.subjectacetogenins
dc.subjectthermosonication-assisted extraction
dc.titleExtraction of Acetogenins Using Thermosonication-Assisted Extraction from Annona muricata Seeds and Their Antifungal Activity
dc.typeArticle


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