Implications of the 5-lipoxygenase allelic variants c.760G>A and -1279 G>T in the nutritional and inflammatory status in Mexican Young Population

dc.creatorGonzález Torres, Yesica Sughey
dc.creatorGonzález Silva, Napoleón
dc.creatorVillagrán De la Mora, Blanca Zuamí
dc.creatorGuzmán Rodríguez, Luis Felipe
dc.creatorPérez Reyes, Ángel
dc.creatorRodríguez Razón, Christian Martín
dc.creatorColima Fausto, Ana Gabriela
dc.creatorVargas Becerra, Patricia Noemi
dc.creatorSánchez Enríquez, Sergio
dc.creatorGarcía García, Maritza Roxana
dc.date2022-09-21T20:26:44Z
dc.date2022-09-21T20:26:44Z
dc.date2019-03
dc.date.accessioned2023-07-21T21:45:52Z
dc.date.available2023-07-21T21:45:52Z
dc.identifierGonzalez-Torres, Yesica Sughey et al. (2020). Implications of the 5-lipoxygenase allelic variants c.760G>A and -1279 G>T in the nutritional and inflammatory status in Mexican Young Population. Metabolism - Clinical and Experimental, Volume 104, 154116
dc.identifier0026-0495
dc.identifierDOI:https://doi.org/10.1016/j.metabol.2019.12.062
dc.identifier1532-8600
dc.identifierhttp://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1418
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7752889
dc.descriptionArtículo
dc.descriptionBackground: The arachidonate 5-lipoxygenase enzyme (5-LOX), which is encoded by the ALOX5 gene, plays a key role in mediating inflammation. Actually, 5-LOX represents a novel target for prevention of metabolic syndrome. Whether ALOX5 genetic variants associate with 5-LOX activity and pathophysiological events is unclear, and interactions of the allelic variants c.760G>A and -1279 G>T with nutritional and inflammatory status have not been studied in Mexican young population. Objective: The present research examines the ALOX5 gene c.760G>A and -1279 G>T variants and their cross-sectional association with inflammatory and nutritional status. Methods: Young volunteers students between the ages of 18 to 25 years old were recruited in Los Altos University Center. Institutional approval was obtained and all participants gave informed consent. Anthropometrical, biochemical, clinical and dietetic evaluations were performed. Genotyping was realized by Taqman Real-Time PCR Assays. The inflammatory biomarkers IL-6, TNFa and CRP were assayed by ELISA. Results: A total of 549 participants (26% men; 74% women) were studied. The frequency of c.760 G>A showed a significant difference between subjects with high vs normal serum levels of very low density lipoprotein cholesterol (c-VLDL) (p=0.007); moreover, almost significant difference was observed between subjects with high vs normal serum levels of c-LDL (p=0.07). Regarding inflammatory cytokines, a statistical trend was found on the IL-6 serum levels between c.760 G>A genotypes. No significant associations between -1279 G>T genotypes and inflammatory markers were observed. Conclusion: Our findings suggest that the c.760 G>A in the ALOX5 gene could be associated with inflammation and nutritional status.
dc.languageen
dc.publisherElsevier - Science Direct
dc.relationMetabolism - Clinical and Experimental;Vol. 103, suppl, 154116, March 01, 2020
dc.subjectALOX5 gene
dc.subjectinflammation
dc.subjectmetabolic syndrome
dc.titleImplications of the 5-lipoxygenase allelic variants c.760G>A and -1279 G>T in the nutritional and inflammatory status in Mexican Young Population
dc.typeArticle


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