Sexual Dimorphism of the Neuroimmunoendocrine Response in the Spleen during a Helminth Infection: A New Role for an Old Player?

dc.creatorNava Castro, Karen Elizabeth
dc.creatorPavón, Lenin
dc.creatorBecerril Villanueva, Luis Enrique
dc.creatorPonce Regalado, María Dolores
dc.creatorAguilar Díaz, Hugo
dc.creatorSegovia Mendoza, Mariana
dc.creatorMorales Montor, Jorge
dc.date2022-06-22T18:18:12Z
dc.date2022-06-22T18:18:12Z
dc.date2022-03
dc.date.accessioned2023-07-21T21:45:25Z
dc.date.available2023-07-21T21:45:25Z
dc.identifierNava-Castro, K.E.; Pavón, L.; Becerril-Villanueva, L.E.; PonceRegalado, M.D.; Aguilar-Díaz, H.; Segovia-Mendoza, M.; Morales-Montor, J. Sexual Dimorphism of the Neuroimmunoendocrine Response in the Spleen during a Helminth Infection: A New Role for an Old Player? Pathogens 2022, 11, 308. https://doi.org/10.3390/ pathogens11030308
dc.identifier2076-0817 Online
dc.identifier2076-0817 (Linking)
dc.identifierDOI: 10.3390/pathogens11030308
dc.identifierhttp://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1351
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7752825
dc.descriptionArtículo
dc.descriptionThe interaction of the nervous, immune, and endocrine systems is crucial in maintaining homeostasis in vertebrates, and vital in mammals. The spleen is a key organ that regulates the neuroimmunoendocrine system. The Taenia crassiceps mouse system is an excellent experimental model to study the complex host-parasite relationship, particularly sex-associated susceptibility to infection. The present study aimed to determine the changes in neurotransmitters, cytokines, sex steroids, and sex-steroid receptors in the spleen of cysticercus-infected male and female mice and whole parasite counts. We found that parasite load was higher in females in comparison to male mice. The levels of the neurotransmitter epinephrine were significantly decreased in infected male animals. The expression of IL-2 and IL-4 in the spleen was markedly increased in infected mice; however, the expression of Interleukin (IL)-10 and interferon (IFN)-γ decreased. We also observed sex-associated differences between non-infected and infected mice. Interestingly, the data show that estradiol levels increased in infected males but decreased in females. Our studies provide evidence that infection leads to changes in neuroimmunoendocrine molecules in the spleen, and these changes are dimorphic and impact the establishment, growth, and reproduction of T. crassiceps. Our findings support the critical role of the neuroimmunoendocrine network in determining sex-associated susceptibility to the helminth parasite.
dc.languageen
dc.publisherMDPI
dc.relationPathogens;2022, 11, 308
dc.subjecthelminths
dc.subjecttaenia crassiceps
dc.subjectcysticercosis
dc.subjectcytokines; immunity
dc.subjectinfection
dc.subjectneuroimmunoendocrinology
dc.subjectneurotransmitters
dc.subjectparasite immunity
dc.subjectsexual dimorphism
dc.subjectspleen
dc.titleSexual Dimorphism of the Neuroimmunoendocrine Response in the Spleen during a Helminth Infection: A New Role for an Old Player?
dc.typeArticle


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