Association of serum levels of IL-1beta, IL-6 and TNF-alpha with personality dimensions and anxiety or depressive symptoms in patients with skin cancer

Abstracts

dc.creatorRamírez De los Santos, María Luisa
dc.creatorLópez Navarro, Araceli
dc.creatorGuzmán Flores, Juan Manuel
dc.creatorViveros Paredes, Juan Manuel
dc.creatorGarcía García, Maritza Roxana
dc.creatorCaldera Montes, Juan Francisco
dc.creatorRamírez De los Santos, Saúl
dc.creatorLópez Pulido, Edgar Iván
dc.date2022-03-15T19:42:14Z
dc.date2022-03-15T19:42:14Z
dc.date2021-10
dc.date.accessioned2023-07-21T21:45:06Z
dc.date.available2023-07-21T21:45:06Z
dc.identifierRamírez-De los Santos M.L., López Navarro A., Guzmán Flores J.M., Viveros Paredes, J.M, García García M.R., Caldera Montes J.F., Ramírez De los Santos S & López-Pulido E.I. (2021). Association of serum levels of IL-1beta, IL-6 and TNF-alpha with personality dimensions and anxiety or depressive symptoms in patients with skin cáncer. Brain, Behavior, and Immunity 98 (2021) 1–55. http://dx.doi.org/10.1016/j.bbi.2021.08.152
dc.identifier0889-1591
dc.identifierhttp://dx.doi.org/10.1016/j.bbi.2021.08.152
dc.identifierhttp://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1310
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7752787
dc.descriptionBackground: Cancer patients frequently manifest anxiety or depression symptoms. It has been described that alteration in moods can trigger an organic reaction that could be related with proinflammatory responses. Methods: The study included Sixty Mexican patients with clinical histopathology diagnosis of skin cancer. The questionnaires of Calderón’s depressive syndrome and Eysenck’s personality were applied. The serum levels of IL-1beta, IL6 and TNF-alpha were obtained using the ELISA technique. The MannWhitney U test and Spearman correlation method were performed with a significance level set at p<0.05. Results: Values of IL-1beta, IL-6 and TNF-alpha were not affected by the presence of anxiety or depression symptomatology. Also, no correlation was detected between cytokines values and personality dimensions. On the other hand, we found correlations between the score of depression versus neuroticism (r=0.767, p<.001) and psychoticism (r=0.425, p<0.01); IL-1beta versus IL-6 (r=0.808, p<0.001), IL-1beta versus TNF alpha (r=0.568, p<0.001), and IL-6 versus TNF alpha (r=0.532, p<0.001). Conclusions: Although, no significant relation among cytokines serum levels with anxiety/depressive symptoms or personality dimensions were demonstrated. We encounter that personality, and the manifestation of depression are related. Furthermore, the results obtained supports a proinflammatory mechanism involved in skin cancer.
dc.languageen
dc.publisherElsevier ClinicalKey
dc.relationBrain, Behavior, and Immunity;98 (2021) 1–55
dc.subjectskin cancer
dc.subjectIL-1beta
dc.subjectIL-6
dc.subjectTNF-alpha
dc.subjectdepressive
dc.subjectanxiety
dc.titleAssociation of serum levels of IL-1beta, IL-6 and TNF-alpha with personality dimensions and anxiety or depressive symptoms in patients with skin cancer
dc.titleAbstracts
dc.typeArticle


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