Effect of Ursolic Acid on Insulin Resistance and Hyperinsulinemia in Rats with Diet-Induced Obesity: Role of Adipokines Expression

dc.creatorGonzález Garibay, Angélica S
dc.creatorLópez Vázquez, Alfonso
dc.creatorGarcía Bañuelos, Jesús
dc.creatorSánchez Enríquez, Sergio
dc.creatorSandoval Rodríguez, Ana S
dc.creatorDel Toro Arreola, Susana
dc.creatorBueno Topete, Miriam Ruth
dc.creatorMuñoz Valle, José Francisco
dc.creatorGonzález Hita, Mercedes Elvira
dc.creatorDomínguez Rosales, José Alfredo
dc.creatorArmendáriz Borund, Juan
dc.creatorBastidas Ramírez, Blanca Estela
dc.date2022-02-16T18:21:56Z
dc.date2022-02-16T18:21:56Z
dc.date2020-03
dc.date.accessioned2023-07-21T21:44:56Z
dc.date.available2023-07-21T21:44:56Z
dc.identifierAngélica S. González-Garibay, Alfonso López-Vázquez, Jesús García-Bañuelos, Sergio Sánchez-Enríquez, Ana S. Sandoval-Rodríguez, Susana Del Toro Arreola, Miriam R. Bueno-Topete, José F. Muñoz-Valle, Mercedes E. González Hita, José A. Domínguez-Rosales, Juan Armendáriz-Borunda, and Blanca E. Bastidas-Ramírez.Journal of Medicinal Food.Mar 2020.297-304.http://doi.org/10.1089/jmf.2019.0154
dc.identifier1096-620X
dc.identifierhttp://doi.org/10.1089/jmf.2019.0154
dc.identifierhttp://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1289
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7752765
dc.descriptionArtículo
dc.descriptionAbstract Excess of visceral adipose tissue (VAT) characteristic of obesity leads to a proinflammatory state disrupting the insulin signaling pathway, triggering insulin resistance (IR) and inflammation, the main processes contributing to obesity comorbidities. Ursolic acid (UA), a pentacyclic triterpenoid occurring in a variety of plant foods, exhibits anti-inflammatory properties. The aim of this study was to evaluate UA effects on IR, hyperinsulinemia, and inflammation in experimental diet-induced obesity. Forty male Wistar rats were randomly assigned to eight groups (n = 5). One group was used for time 0. Three groups were labeled as OBE (control): receiving high-fat diet (HFD; fat content 45.24% of energy) during 3, 6, or 9 weeks; three groups UA-PREV: exposed to simultaneous HFD and UA during 3, 6, or 9 weeks to evaluate UA preventive effects; one group UA-REV: receiving HFD for 6 weeks, followed by simultaneous HFD and UA for three additional weeks to analyze UA reversal effects. Measurements were performed after 3, 6, or 9 weeks of treatment. Adiposity was calculated by weighing VAT after sacrifice. Serum markers were quantified through colorimetric and enzyme-linked immunosorbent assay methods. VAT adipokines RNAm expression was evaluated by quantitative reverse transcriptase–polymerase chain reaction. Data were analyzed by Kruskal–Wallis and Mann–Whitney U tests. UA significantly decreased adiposity, IR, hyperinsulinemia, triacylglycerides, and cholesterol levels, and also VAT mRNA expression of MCP-1 (monocyte chemoattractant protein-1), IL (interleukin)-1β and IL-6, concomitantly increasing adiponectin levels. UA metabolic effects demonstrated in this study support its potential therapeutic utility to improve IR, hyperinsulinemia, and inflammation observed in obesity and diabetes.
dc.languageen
dc.publisherMary Ann Liebert, Inc., publishers
dc.relationJournal of Medicinal Food;Vol. 23, No. 3
dc.subjectadiposity
dc.subjectdyslipidemia
dc.subjectnutraceutics
dc.subjectT2D
dc.titleEffect of Ursolic Acid on Insulin Resistance and Hyperinsulinemia in Rats with Diet-Induced Obesity: Role of Adipokines Expression
dc.typeArticle


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