Microcephaly, an etiopathogenic vision

dc.creatorBecerra Solano, Luis Eduardo
dc.creatorMateos Sanchez, Leovigildo
dc.creatorLopez Munoz, Eunice
dc.date2021-11-17T19:24:12Z
dc.date2021-11-17T19:24:12Z
dc.date2021-07
dc.date.accessioned2023-07-21T21:44:07Z
dc.date.available2023-07-21T21:44:07Z
dc.identifierBecerra Solano L.E., Mateos Sánchez L., López Muñoz E., (2021). Microcephaly, an etiopathogenic visión. Pediatrics & Neonatology, Volume 62, Issue 4. Pages 354-360. ISSN 1875-9572. DOI: https://doi.org/10.1016/j.pedneo.2021.05.008.
dc.identifier1875-9572
dc.identifierhttps://doi.org/10.1016/j.pedneo.2021.05.008.
dc.identifierhttp://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1182
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7752662
dc.descriptionArtículo
dc.descriptionMicrocephaly is defined by an occipital-frontal head circumference (OFD) 2 standard deviations (SD) smaller than the average expected for age, gender and population. Its incidence has been reported between 1.3 and 150 cases per 100,000 births. Currently, new clinical characteristics, causes and pathophysiological mechanisms related to microcephaly continue to be identified. Its etiology is varied and heterogeneous, with genetic and non-genetic factors that produce alterations in differentiation, proliferation, migration, repair of damage to deoxyribonucleic acid and neuronal apoptosis. It requires a multidisciplinary diagnostic approach that includes a medical history, detailed prenatal and postnatal clinical evaluation, cerebral magnetic resonance imaging, neuropsychological evaluation, and in some cases complementary tests such as metabolic screening, tests to rule out infectious processes and genetic testing. There is no specific treatment or intervention to increase cerebral growth; however, timely intervention strategies and programs can be established to improve motor and neurocognitive development, as well as to provide genetic counseling. The objective of this work is to review the available information and reinforce the proposal to carry out an etiopathogenic approach for microcephaly diagnosis and management.
dc.languageen
dc.publisherScienceDirect
dc.relationPediatrics and Neonatology;Vol. 62. Issue 4. (2021) 354-360
dc.subjectacquired microcephaly
dc.subjectcongenital microcephaly
dc.subjectisolated microcephaly
dc.subjectmicrocephaly primary hereditary (MCPH)
dc.subjectSyndromicmicrocephaly
dc.titleMicrocephaly, an etiopathogenic vision
dc.typeArticle


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