MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer

dc.creatorMuñiz Mendoza, Rodolfo
dc.creatorAyala Madrigal, María de la Luz
dc.creatorPartida Pérez, Miriam
dc.creatorPeregrina Sandoval, Jorge
dc.creatorLeal Ugarte, Evelia
dc.creatorMacías Gómez, Nelly
dc.creatorPeralta Leal, Valeria
dc.creatorMeza Espinoza, Juan Pablo
dc.creatorMoreno Ortiz, José Miguel
dc.creatorRamírez Ramírez, Ruth
dc.creatorSuárez Villanueva, Alexis Sayuri
dc.creatorGutiérrez Angulo, Melva
dc.date2015-07-22T16:38:35Z
dc.date2015-07-22T16:38:35Z
dc.date2012-06
dc.date.accessioned2023-07-21T21:39:30Z
dc.date.available2023-07-21T21:39:30Z
dc.identifierMuñiz-Mendoza, R., Ayala-Madrigal, M. L., Partida-Pérez, M., Peregrina-Sandoval, J., Leal-Ugarte, E., Macías-Gómez, N., … Gutiérrez-Angulo, M. (2012). MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer. Genetics and Molecular Research, 11(3), 2315–2320. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/22843073
dc.identifier1676-5680
dc.identifierDOI: 10.4238/2012.June.27.6
dc.identifierhttp://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/359
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7752042
dc.descriptionDNA repair proteins maintain DNA integrity; polymorphisms in genes coding for these proteins can increase susceptibility to colorectal cancer (CRC) development. We analyzed a possible association of MLH1 -93G>A and 655A>G and XRCC1 Arg194Trp and Arg399Gln polymorphisms with CRC in Mexican patients. Genomic DNA samples were obtained from peripheral blood of 108 individuals with CRC (study group) at diagnosis and 120 blood donors (control group) from Western Mexico; both groups were mestizos. The polymorphisms were detected by PCR-RFLP. Association was estimated by calculating the odds ratio (OR). We found that the MLH1 and XRCC1 polymorphisms were in Hardy-Weinberg equilibrium. The MLH1 655A>G polymorphism in the 655G allele was associated with a 2-fold increase risk for CRC (OR = 2.04 and 95% confidence interval (95%CI) = 1.12-3.69; P < 0.01), while the MLH1 -93G>A polymorphism allele was associated with a protective effect (OR = 0.60, 95%CI = 0.40-0.89; P = 0.01 in the -93A allele and OR = 0.32, 95%CI = 0.13-0.79; P = 0.01 in the AA genotype). The XRCC1 Arg194Trp and Arg399Gln polymorphisms did not show any significant associations. In conclusion, we found that MLH1 -93G>A and 655A>G polymorphisms are associated with CRC in Mexican patients.
dc.descriptionInstituto de Genética Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México Laboratorio de Inmunobiología, Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara, Zapopan, Jalisco, México Facultad de Medicina e Ingeniería en Sistemas Computacionales, Universidad de Tamaulipas, Matamoros, Tamaulipas, México Laboratorio de Genética Humana, Centro Universitario del Sur, Universidad de Guadalajara, Ciudad Guzmán, Jalisco, México Departamento de Clínicas, Centro Universitario de Los Altos, Universidad de Guadalajara, Tepatitlán de Morelos, Jalisco, México
dc.languageen
dc.publisherFundação de Pesquisas Científicas de Ribeirão Preto. Brasil.
dc.relationGenetics and Molecular Research;11 (3): 2315 - 2320
dc.subjectMLH1 gene
dc.subjectXRCC1 gene
dc.subjectcolorectal cancer
dc.subjectmexican population
dc.titleMLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer
dc.typeArticle


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