Increased expression of AML1-a and acquired chromosomal abnormalities in childhood acute lymphoblastic leukemia

Review article

dc.creatorGutiérrez Angulo, Melva
dc.creatorGonzález García, Juan Ramón
dc.creatorMeza Espinoza, Juan Pablo
dc.creatorPicos Cárdenas, V.J.
dc.creatorEsparza Flores, M.A.
dc.creatorLópez Guido, B.
dc.creatorRivera, Horacio
dc.date2015-07-22T16:37:32Z
dc.date2015-07-22T16:37:32Z
dc.date2004-09
dc.date.accessioned2023-07-21T21:39:29Z
dc.date.available2023-07-21T21:39:29Z
dc.identifierGutiérrez-Angulo, M., González-García, J. R., Meza-Espinoza, J. P., Picos-Cárdenas, V. J., Esparza-Flores, M. a., López-Guido, B., & Rivera, H. (2004). Increased expression of AML1-a and acquired chromosomal abnormalities in childhood acute lymphoblastic leukemia. Hematological Oncology, 22(3), 85–90. http://doi.org/10.1002/hon.734
dc.identifierhttp://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/358
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7752041
dc.descriptionA semi-quantitative expression analysis of both AML1-a and AML1-total was performed by RT-PCR in 19 children with acute lymphoblastic leukemia (ALL) at diagnosis. AML1-a expression was assessed in 16 bone marrow (BM) and 13 peripheral blood (PB) samples whereas AML1-total was assessed in 17 BM and 16 PB samples. These analyses were also carried out in 15 PB samples of healthy controls. In addition, 18/19 patients were karyotyped: 11 had an unmodified constitutional karyotype (CK) and seven exhibited acquired chromosomal abnormalities (ACA). The expression of AML1-a was significantly increased in BM and PB when compared with the controls (p < 0.013 and p < 0.035, respectively). A significant increase was found in the expression of AML1-a in BM of the ACA group compared with the CK group (p < 0.0009). The expression of AML1-a in BM and PB showed a significant increase in the ACA group compared with controls (p < 0.00001 and p < 0.012, respectively); in contrast, the CK group did not differ from the controls. These observations may mean that the increase of AML1-a favours the progression of leukemia.
dc.descriptionDivisión de Genética, Centro de Investigación Biomédica de Occidente, IMSS, Tepatitlán, Jalisco, México Departamento de Hematología, Hospital de Pediatría, IMSS, Tepatitlán, Jalisco, México Universidad de Guadalajara, Centro Universitario de los Altos, Tepatitla´n, Jalisco, México. CONACYT; contract/grant numbers: 39024-M; 117466; 12445 and 124931.
dc.languageen
dc.publisherWiley Online Library
dc.relationHematological Oncology;Volume 22, Issue 3, pages 85–90, September 2004
dc.subjectAML1-a isoform
dc.subjectgene expression
dc.subjectacquired chromosomal abnormalities
dc.titleIncreased expression of AML1-a and acquired chromosomal abnormalities in childhood acute lymphoblastic leukemia
dc.titleReview article
dc.typeArticle


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