| dc.contributor | Public Library of Science | |
| dc.creator | Juárez Montiel, Margarita | |
| dc.creator | Romero Maldonado, Andrea | |
| dc.creator | Monreal Escalante, Elizabeth | |
| dc.creator | Rosales Mendoza, Sergio | |
| dc.creator | Jiménez Bremont, Juan Francisco | |
| dc.date | 2018-03-23T23:59:44Z | |
| dc.date | 2018-03-23T23:59:44Z | |
| dc.date | 2015-07 | |
| dc.date.accessioned | 2023-07-17T22:05:15Z | |
| dc.date.available | 2023-07-17T22:05:15Z | |
| dc.identifier | Juárez-Montiel M, Romero-Maldonado A, Monreal-Escalante E, Becerra-Flora A, Korban SS, Rosales-Mendoza S, et al. (2015) The Corn Smut (‘Huitlacoche’) as a New Platform for Oral Vaccines. PLoS ONE 10(7): e0133535. https://doi.org/10.1371/journal.pone.0133535 | |
| dc.identifier | http://hdl.handle.net/11627/3718 | |
| dc.identifier | https://doi.org/10.1371/journal.pone.0133535 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/7544310 | |
| dc.description | "The development of new alternative platforms for subunit vaccine production is a priority in the biomedical field. In this study, Ustilago maydis, the causal agent of common corn smut or 'huitlacoche' has been genetically engineered to assess expression and immunogenicity of the B subunit of the cholera toxin (CTB), a relevant immunomodulatory agent in vaccinology. An oligomeric CTB recombinant protein was expressed in corn smut galls at levels of up to 1.3 mg g(-1) dry weight (0.8% of the total soluble protein). Mice orally immunized with 'huitlacoche'-derived CTB showed significant humoral responses that were well-correlated with protection against challenge with the cholera toxin (CT). These findings demonstrate the feasibility of using edible corn smut as a safe, effective, and low-cost platform for production and delivery of a subunit oral vaccine. The implications of this platform in the area of molecular pharming are discussed." | |
| dc.format | application/pdf | |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.rights | Acceso Abierto | |
| dc.subject | OTRAS ESPECIALIDADES TECNOLÓGICAS | |
| dc.title | The corn smut (‘Huitlacoche’) as a new latform for oral vaccines | |
| dc.type | article | |
