Consumption of Amaranth Induces the Accumulation of the Antioxidant Protein Paraoxonase/Arylesterase 1 and Modulates Dipeptidyl Peptidase IV Activity in Plasma of Streptozotocin-Induced Hyperglycemic Rats

dc.contributorKarger
dc.creatorVelarde Salcedo, Aida Jimena
dc.creatorRegalado Rentería, Evelyn
dc.creatorJuárez Flores, Bertha Irene
dc.creatorBarrera Pacheco, Alberto
dc.creatorBarba de la Rosa, Ana Paulina
dc.creatorVelarde Salcedo, Rodrigo
dc.creatorGonzález de Mejía, Elvira
dc.date2018-07-11T18:29:39Z
dc.date2018-07-11T18:29:39Z
dc.date2017
dc.date.accessioned2023-07-17T22:04:14Z
dc.date.available2023-07-17T22:04:14Z
dc.identifierJ Nutrigenet Nutrigenomics 2017;10:181-193 (DOI:10.1159/000486482).
dc.identifierhttp://hdl.handle.net/11627/4011
dc.identifierhttps://doi.org/10.1159/000486482
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7543881
dc.description"Scope: Amaranth grain is a source of several bioactive compounds such as cancer-preventive and ACE inhibitory peptides. In vitro analysis of amaranth proteins has also demonstrated the presence of bioactive peptides, which exert inhibitory activity upon dipeptidyl peptidase IV (DPPIV), a new target for type 2 diabetes, but this potential activity has not been tested in vivo. The aim of this work was to evaluate whether chronic amaranth consumption has a beneficial effect in streptozotocin-induced diabetic rats, particularly in DPPIV activity and changes in plasma proteome profile. Methods and results: Diabetic rats were fed with 20% popped amaranth grain diet for 12 weeks. Changes in lipid profile, DPPIV activity in plasma and kidney, as well changes in plasma proteome were evaluated. Total cholesterol and DPPIV activity in plasma were increased in diabetic rats but this was ameliorated by amaranth consumption. Diabetic rats fed with amaranth showed the highest levels of HDL and this correlated with an accumulation of apolipoprotein (apo) A-II. Furthermore, amaranth diet stimulated the up-accumulation of the antioxidant protein paraoxonase 1(PON1). Conclusion This study provides molecular evidence about the role of amaranth as a potential functional food with DPPIV inhibitory activity and with a positive effect in plasma lipoproteins."
dc.formatapplication/pdf
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rightsembargoedAccess
dc.subjectAmaranth
dc.subjectBioactive peptides
dc.subjectDiabetes
dc.subjectDipeptidyl peptidase IV
dc.subjectPlasma proteomics
dc.subjectGENÉTICA
dc.titleConsumption of Amaranth Induces the Accumulation of the Antioxidant Protein Paraoxonase/Arylesterase 1 and Modulates Dipeptidyl Peptidase IV Activity in Plasma of Streptozotocin-Induced Hyperglycemic Rats
dc.typearticle


Este ítem pertenece a la siguiente institución