Synchronization and activation in a model of a network of β-cells

dc.contributorElsevier
dc.creatorBarajas Ramírez, Juan Gonzalo
dc.creatorSteur, Erik
dc.creatorFemat Flores, Alejandro Ricardo
dc.creatorHenk Nijmeijer
dc.date2018-11-15T18:58:47Z
dc.date2018-11-15T18:58:47Z
dc.date2011
dc.date.accessioned2023-07-17T22:02:13Z
dc.date.available2023-07-17T22:02:13Z
dc.identifierJ.G. Barajas-Ramírez, E. Steur, R. Femat, H. Nijmeijer, Synchronization and activation in a model of a network of β-cells, Automatica, Volume 47, Issue 6, 2011, Pages 1243-1248.
dc.identifierhttp://hdl.handle.net/11627/4755
dc.identifierhttps://doi.org/10.1016/j.automatica.2011.02.041
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7542992
dc.description"Islets of pancreatic β-cells are of utmost importance in the understanding of diabetes mellitus. We consider here a model of a network of such pancreatic β-cells which are globally coupled via gap junctions. Some of the cells in the islet produce bursting oscillations while other cells are inactive. We prove that the cells in the islet synchronize if the coupling is sufficiently large and all cells are active (or inactive). If the islet consists of both active and inactive cells and the coupling is sufficiently large, an active cluster and an inactive cluster emerge. We show that activity of the islet depends on the coupling strength and the number of active cells compared to the number of inactive cells. If too few cells are active the islet becomes inactive."
dc.formatapplication/pdf
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rightsAcceso Abierto
dc.subjectNetwork synchronization
dc.subjectβ Cells
dc.subjectActivation
dc.subjectCoupling
dc.subjectMATEMÁTICAS
dc.titleSynchronization and activation in a model of a network of β-cells
dc.typearticle


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