Melatonin provides an innovative neuroprotective strategy by combining its effects on sleep with its cytoprotective properties. Melatonin protects against several mechanisms of neuronal death, including oxyradical-mediated damage and apoptosis implicated in the pathogenesis of a number of neurodegenerative diseases like AD, Parkinsonism, Huntington’s chorea and neurological conditions like stroke, epilepsy and brain trauma.Sociedad Argentina de Fisiología