Articulo
Sputnik V Vaccine Elicits Seroconversion and Neutralizing Capacity to SARS CoV-2 after a Single Dose
Registro en:
issn:2666-3791
Autor
Rossi, Andrés Hugo
Ojeda, Diego Sebastian
Varese, Augusto
Sanchez, Lautaro
Gonzalez Lopez Ledesma, Maria M.
Mazzitelli, Ignacio
Alvarez Juliá, Anabel
Oviedo Rouco, Santiago
Pallarés, Horacio M.
Costa Navarro, Guadalupe S.
Rasetto, Natali B.
García, Corina I.
Wenker, Shirley D.
Ramis, Lila Y.
Bialer, Magalí G.
Leone, María José de
Hernando, C. Esteban
Sosa, Santiago
Bianchimano, Luciana
Rios, Antonella S.
Treffinger Cienfuegos, Maria Soledad
Caramelo, Julio J.
Longueira, Yesica
Laufer, Natalia
Alvarez, Diego E.
Carradori, Jorge
Pedrozza, Dariana
Rima, Alejandra
Echegoyen, Cecilia
Ercole, Regina
Gelpi, Paula
Marchetti, Susana
Zubieta, Martín
Docena, Guillermo Horacio
Kreplak, Nicolás
Yanovsky, Marcelo J.
Geffner, Jorge
Pifano, Marina
Gamarnik, Andrea V.
Institución
Resumen
Massive vaccination offers great promise for halting the global COVID-19 pandemic. However, limited supply and uneven vaccine distribution create an urgent need to optimize vaccination strategies. We evaluate SARS-CoV-2-specific antibody responses after Sputnik V vaccination of healthcare workers in Argentina, measuring IgG anti-spike titers and neutralizing capacity after one and two doses in a cohort of naive or previously infected volunteers. By 21 days after receiving the first dose of vaccine, 94% of naive participants develop spike-specific IgG antibodies. A single Sputnik V dose elicits higher antibody levels and virus neutralizing capacity in previously infected individuals than in naive ones receiving the full two-dose schedule. The high seroconversion rate after a single dose in naive participants suggests a benefit of delaying second dose administration to increase the number of people vaccinated. The data presented provide information for guiding public health decisions in light of the current global health emergency. Instituto de Estudios Inmunológicos y Fisiopatológicos