Effect of resveratrol administration on metabolic syndrome, insulin sensitivity, and insulin secretion

Abstract

Composite boards of sugar cane bagasse particles and recycled high-density polyethylene were manufactured by means of a flat press process under laboratory conditions using a partial factorial experimental design (2K-1) to determine the effects of the process variables press temperature, pressing time, bagasse/plastic content and pressure on bending properties, water absorption and thickness swelling. The sugar cane bagasse particles varied in size from 2 to 15 mm, the plastic particles from 1 to 3 mm. Nominal board dimensions and density were 300 mm 300 mm 5 mm and 0.75 g/cm3, respectively. The following process conditions were implemented: press temperature 140 and 160 °C, pressing time 6 and 12 min, bagasse/plastic content 40/60% and 60/40%, and pressure 3 and 6 MPa. Bending strength (MOR) and bending modulus of elasticity (MOE) increased proportionally with press temperature and pressing time. An increase of the bagasse content had a positive effect only on bending MOE. An increase in pressure had a negative effect on both bending strength and MOE. Water absorption and thickness swelling were reduced significantly by an increase in temperature and pressing time, whereas variation of pressure did not have any influence on these board properties. " 2007 Elsevier B.V. All rights reserved.",,,,,,"10.1016/j.indcrop.2006.12.014",,,"http://hdl.handle.net/20.500.12104/40992","http://www.scopus.com/inward/record.url?eid=2-s2.0-34247141926&partnerID=40&md5=4467a5902271d8a93dc6cd53adcf1629",,,,,,"1",,"Industrial Crops and Products",,"1

7",,"26",,"Scopus

WOS",,,,,,"Bending properties; Composite boards; High density polyethylene; Sugar cane bagasse; Thickness swelling; Water absorption",,,,,,"Effect of production variables on bending properties, water absorption and thickness swelling of bagasse/plastic composite boards",,"Article" "42778","123456789/35008",,"Méndez-Del Villar, M., Institute of Experimental and Clinical Therapeutics, Department of Physiology, University of GuadalajaraGuadalajara, Mexico; González-Ortiz, M., Institute of Experimental and Clinical Therapeutics, Department of Physiology, University of GuadalajaraGuadalajara, Mexico; Martínez-Abundis, E., Institute of Experimental and Clinical Therapeutics, Department of Physiology, University of GuadalajaraGuadalajara, Mexico; Pérez-Rubio, K.G., Institute of Experimental and Clinical Therapeutics, Department of Physiology, University of GuadalajaraGuadalajara, Mexico; Lizárraga-Valdez, R., Institute of Experimental and Clinical Therapeutics, Department of Physiology, University of GuadalajaraGuadalajara, Mexico",,"Mendez-Del Villar, M.

Gonzalez-Ortiz, M.

Martinez-Abundis, E.

Perez-Rubio, K.G.

Lizarraga-Valdez, R.",,"2014",,"Aim: This study evaluated the effect of resveratrol administration on metabolic syndrome, insulin sensitivity, and insulin secretion. Methods: A randomized, double-blind, placebo-controlled clinical trial was carried out in 24 patients with diagnosis of metabolic syndrome in accordance with the International Diabetes Federation criteria. Glucose and insulin levels were measured after a 75-gram dextrose load. Triglycerides and high-density lipoprotein cholesterol concentrations at baseline were also evaluated. Twelve patients received trans-resveratrol (500mg) three times per day before meals for 90 days. The remaining 12 patients received placebo at the same dose. The area under the curve (AUC) values of glucose and insulin, total insulin secretion, first-phase of insulin secretion, and insulin sensitivity were calculated. Results: After resveratrol administration, there were significant differences in total weight (94.4 13.2 vs. 90.5 12.3kg, P=0.007), body mass index (BMI) (35.6 3.2 vs. 34.3 3.0kg/m2, P=0.006), fat mass (41.2 7.9 vs. 38.8 6.0kg, P=0.001), and waist circumference (WC) (109 9 vs. 105 10cm, P=0.004). There were also significant differences in AUC of insulin (48,418 22,707 vs. 26,473 8,273pmol/L, P=0.003) and insulinogenic index (0.48 0.22 vs. 0.28 0.08, P=0.004). Conclusions: Administration of resveratrol significantly decreases weight, BMI, fat mass, WC, AUC of insulin, and total insulin secretion. " Mary Ann Liebert, Inc. 2014.