| dc.contributor | Castro-Martínez, X.H., Molecular Medicine Division, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Mexico, Doctorate Program in Human Genetics, Universidad de Guadalajara, Guadalajara, Mexico; Leal-Cortés, C., Surgical Research Division, CIBO, IMSS, Guadalajara, Mexico; Flores-Martínez, S.E., Molecular Medicine Division, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Mexico; García-Zapién, A.G., Molecular Medicine Division, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Mexico; Sánchez-Corona, J., Molecular Medicine Division, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Mexico; Portilla-de Buen, E., Surgical Research Division, CIBO, IMSS, Guadalajara, Mexico; Gómez-Espinel, I., Medicine School, Universidad Autónoma de Nuevo León, Monterrey, Mexico; Zamora-Ginez, I., Centro de Investigación Biomédica de Oriente, IMSS, Puebla, Mexico; Pérez-Fuentes, R., Centro de Investigación Biomédica de Oriente, IMSS, Puebla, Mexico; Islas-Andrade, S., Medical Research Unit in Metabolic Diseases, Centro Médico Nacional Siglo XXI, IMSS, MX, Mexico; Revilla-Monsalve, C., Medical Research Unit in Metabolic Diseases, Centro Médico Nacional Siglo XXI, IMSS, MX, Mexico; Guerrero-Romero, F., Medical Research Unit in Clinical Epidemiology, Hospital General, IMSS, Durango, Mexico; Rodríguez-Morán, M., Medical Research Unit in Clinical Epidemiology, Hospital General, IMSS, Durango, Mexico; Mendoza-Carrera, F., Molecular Medicine Division, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Mexico | |
| dc.description.abstract | The so-called tumor necrosis factor (TNF) block includes the TNFA, lymphotoxin alpha and beta (LTA and LTB) genes with single-nucleotide polymorphisms (SNP) and microsatellites with an allele frequency that exhibits interpopulation variability. To date, no reports have included both SNPs and microsatellites at the TNF block to study Mestizo or Amerindian populations from Mexico. In this study, samples of five Mexican Mestizo populations (Durango, Guadalajara, Monterrey, Puebla, and Tierra Blanca) and four native-Mexican populations (North Lacandonians, South Lacandonians, Tepehuanos, and Yaquis) were genotyped for two SNPs (LTA+252A>G and TNFA-308G>A) and four microsatellites (TNFa, d, e, and f), to analyze the genetic substructure of the Mexican population. Allele and haplotype frequencies, linkage disequilibrium (LD), and interpopulation genetic relationships were calculated. There was significant LD along almost all of the TNF block but the lowest D' values were observed for the TNFf-TNFd pair. Mestizos showed higher allele and haplotype diversity than did natives. The genetic differentiation level was reduced among Mestizos; however, a slightly, but significant genetic substructure was observed between northern and southern Mexican Mestizos. Among the Amerindian populations, the genetic differentiation level was significantly elevated, particularly in both North and South Lacandonians. Furthermore, among Southern Lacandonians, inhabitants of Lacanja town were the most differentiated from all the Mexicans analyzed. The data presented here will serve as a reference for further population and epidemiological studies including these TNF polymorphisms in the Mexican population. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. | |
